ArticleFrontiers in medicine2026
Association between glycated hemoglobin and lipid parameters at the time of type 2 diabetes mellitus diagnosis: evidence from a regional population.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and objectives: Type 2 diabetes mellitus (T2DM) is associated with lipid abnormalities that increase cardiovascular risk; however, evidence regarding this relationship at diagnosis is limited. This study aimed to examine the association between glycated hemoglobin (HbA1c) and lipid parameters at the time of T2DM diagnosis. Methods: A retrospective cross-sectional study included 3,501 newly diagnosed T2DM patients treated within the Riojano Health Service between 2019 and 2025. Multiple linear regression was used to assess associations between HbA1c and lipid parameters. The study was approved by the Research Ethics Committee of La Rioja (CEImLAR, PI 778). Results: HbA1c was positively associated with total cholesterol (TC) (β = 4.25, Conclusion: At diagnosis, higher HbA1c levels were independently associated with a more atherogenic lipid profile-higher TC and TG, and lower HDL-C-highlighting the importance of early metabolic assessment and comprehensive cardiovascular risk management.
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