ArticleFrontiers in immunology2026
Upregulated FASN-mediated lipogenesis in senescent macrophages contributes to liver fibrosis progression.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Liver fibrosis represents a common advanced pathological stage of various chronic liver diseases. Macrophages serve as key regulators of innate immunity and play important roles in the development of liver fibrosis. Cellular senescence is an irreversible cell cycle arrest state. However, the mechanisms underlying the role of senescent macrophages in liver fibrosis remain incompletely understood. Methods: Liver fibrosis was induced in young (8-week) and middle-aged (12-month) mice by intraperitoneal injection of 25% carbon tetrachloride (CCl Results: Conclusion: Macrophages in middle-aged fibrotic livers exhibit cellular senescence. FASN-mediated enhancement of fatty acid synthesis leads to lipid metabolic disorder and accumulation in senescent macrophages. These senescent macrophages promote HSC activation and drive the progression of liver fibrosis.
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