Evidence map›Paper›PMID 42523564›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Evaluating Goodness of Pronunciation and Phonological Posteriors as Objective Markers of Speech Severity in Motor Speech Disorders.

Fenqi Wang, Rene L Utianski, Joseph R Duffy, Leland R Barnard, Hugo Botha

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fenqi WangDepartment of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905 USA.ORCID 0000-0003-2722-0161
Rene L UtianskiDepartment of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905 USA.ORCID 0000-0001-9519-1302
Joseph R DuffyDepartment of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905 USA.ORCID 0000-0001-8206-3432
Leland R BarnardDepartment of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905 USA.ORCID 0000-0003-1569-9312
Hugo BothaDepartment of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905 USA.ORCID 0000-0003-4390-685X

Funding

Automated speech assessment for diagnosis of FTD spectrum disordersR01AG083832 · NIA · MAYO CLINIC ROCHESTER · PI Hugo Botha · 2024 to 2026
$2.4M
NIA NIH HHS R01 AG083832
6 · The paper itself

Abstract

This study examined the extent to which goodness of pronunciation (GoP) scores and phonological posterior probabilities capture perceptual ratings of speech severity in individuals with motor speech disorders (MSD). Speech recordings of the word catastrophe were obtained from 489 participants, including 333 neurologically typical controls and 156 individuals with MSD. GoP scores were derived using traditional acoustic features and self-supervised speech representations, including WavLM and XLS-R, across multiple modeling approaches, while phonological posterior probabilities were extracted using Phonet. Model performance was evaluated using Kendall's rank correlations, regression, and receiver operating characteristic analyses against speech-language pathologists' perceptual ratings of sound distortion and intelligibility. Both GoP and phonological posterior probabilities were significantly associated with perceptual ratings. Self-supervised speech representations substantially outperformed traditional acoustic features, with WavLM-based GoP using k-nearest neighbors achieving the strongest performance. Across correlation, regression, and classification analyses, GoP consistently outperformed phonological posterior probabilities for both sound distortion and intelligibility. Age and gender had minimal influence on model-derived measures or their relationships with perceptual ratings. These findings demonstrate the value of self-supervised GoP as an objective measure of speech impairment while highlighting the complementary role of phonological posterior probabilities in characterizing articulatory aspects of motor speech disorders.

Indexed as

goodness of pronunciationMotor speech disordersphonological posterior probabilitiesspeech severity

Identifiers

PMID42523564
PMCPMC13405531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.