Evidence map›Paper›PMID 42523523›Full record

ArticleResearch square2026

Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer's Disease and Primary Tauopathies.

L Daniel Estrella, Swarnali Dasgupta, Akhila Gundavelli, Huan Li, Stanley H Yang, Sarah Chancellor, Tim Pastika, Aicha Abdourahman, Joseph Tamm, Kiran Yanamandra and 21 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

L Daniel EstrellaMassGeneral Institute for Neurodegenerative Disease.
Swarnali DasguptaMassGeneral Institute for Neurodegenerative Disease.
Akhila GundavelliMassGeneral Institute for Neurodegenerative Disease.
Huan LiMassGeneral Institute for Neurodegenerative Disease.
Stanley H YangAbbVie Inc.
Sarah ChancellorAbbVie Inc.
Tim PastikaAbbVie Inc.
Aicha AbdourahmanAbbVie Inc.
Joseph TammAbbVie Inc.
Kiran YanamandraAbbVie Inc.
Nandani RomanulAbbVie Inc.
Fan LiaoAbbVie Inc.
Karen ZhaoAbbVie Inc.
Gen LinAbbVie Pte Ltd.
Pooja SrinivasaAbbVie Inc.
Xinge WangAbbVie (United States).
Annita MartinAbbVie (United States).
Elizabeth AsqueAbbVie (United States).
Astrid DoeringAbbVie Deutschland GmbH & Company KG.
Janina S RiedAbbVie Deutschland GmbH & Company KG.
Robert V TalanianAbbVie Inc.
Taekyung KwonAbbVie Inc.
Maya E WoodburyAbbVie Inc.
Yelena Y GrinbergAbbVie Inc.
Ergina AgastraMassGeneral Institute for Neurodegenerative Disease.
Derek H OakleyMassachusetts General Hospital.
Bradley T HymanMassGeneral Institute for Neurodegenerative Disease.
Alberto Serrano-PozoMassGeneral Institute for Neurodegenerative Disease.
Theodore ZwangMassGeneral Institute for Neurodegenerative Disease.
Sudeshna DasMassGeneral Institute for Neurodegenerative Disease.
Rachel E BennettMassGeneral Institute for Neurodegenerative Disease.

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Microvascular Stress as a Pathway to Neurodegeneration in Alzheimer'sR01AG071567 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Rachel Elise Bennett · 2022 to 2026
$2.1M
NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG071567
6 · The paper itself

Abstract

Cerebrovascular alterations are widely observed in both Alzheimer's Disease (AD) and primary tauopathies. Here, we hypothesized that mechanisms of cerebrovascular alterations are shared between AD and primary tauopathies. We performed single-nucleus RNA sequencing of

Identifiers

PMID42523523
PMCPMC13405430

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.