Evidence map›Paper›PMID 42523516›Full record

ArticlebioRxiv : the preprint server for biology2026

Structure-activity of outer membrane proteins in native bacterial membrane vesicles by solid-state NMR.

Tata Gopinath, Kyungsoo Shin, Swapna Bera, Alyssa Kraft, Karthika Samimuthu, Ashish K Gadicherla, James E Kent, Nicholas A Wood, Francesca M Marassi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tata GopinathDepartment of Biophysics, Medical College of Wisconsin 8701 Watertown Plank Road, Milwaukee, WI 53226-3548 USA.ORCID 0000-0002-5237-2135
Kyungsoo ShinDepartment of Biophysics, Medical College of Wisconsin 8701 Watertown Plank Road, Milwaukee, WI 53226-3548 USA.ORCID 0000-0003-4836-8798
Swapna BeraDepartment of Biophysics, Medical College of Wisconsin 8701 Watertown Plank Road, Milwaukee, WI 53226-3548 USA.ORCID 0000-0002-2094-045X
Alyssa KraftDepartment of Biophysics, Medical College of Wisconsin 8701 Watertown Plank Road, Milwaukee, WI 53226-3548 USA.ORCID 0009-0008-7549-4064
Karthika SamimuthuDepartment of Biophysics, Medical College of Wisconsin 8701 Watertown Plank Road, Milwaukee, WI 53226-3548 USA.
Ashish K GadicherlaDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin 8701 Watertown Plank Road, Milwaukee, WI 53226-3548 USA.ORCID 0000-0001-7013-4264
James E KentPresent address: Qpex Biopharma, 10075 Barnes Canyon Rd, San Diego, CA 92121 USA.ORCID 0000-0002-4856-525X
Nicholas A WoodDepartment of Biophysics, Medical College of Wisconsin 8701 Watertown Plank Road, Milwaukee, WI 53226-3548 USA.ORCID 0000-0003-2527-5441
Francesca M MarassiDepartment of Biophysics, Medical College of Wisconsin 8701 Watertown Plank Road, Milwaukee, WI 53226-3548 USA.ORCID 0000-0003-2695-5844

Funding

Membrane Protein Effectors of Pathogen Interactions With HostR35GM118186 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Francesca M Marassi · 2016 to 2026
$8.5M
A 600 MHz NMR spectrometer upgrade for the Sanford Burnham Prebys Cancer CenterS10OD028716 · OD · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MARASSI, FRANCESCA M · 2020 to 2020
$926k
Multi-disciplinary analysis of the role of PagC for outer membrane vesicle biogenesisF32AI188770 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Nicholas A Wood · 2025 to 2026
$152k
NIAID NIH HHS F32 AI188770NIGMS NIH HHS R35 GM118186NIH HHS S10 OD028716
6 · The paper itself

Abstract

The outer membranes (OMs) of bacterial pathogens are potent virulence factors and serve as the first line of defense against host immunity. Their striking bilayer asymmetry is essential for function but poses an exceptional challenge for reconstitution

Indexed as

bacteriaouter membrane proteinouter membrane vesiclesolid-state NMR

Identifiers

PMID42523516
PMCPMC13405413

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.