Evidence map›Paper›PMID 42523504›Full record

ArticlebioRxiv : the preprint server for biology2026

NPC1 deficiency engages a lysosome-genome-immune program linked to neurodegeneration and cellular aging signatures.

Morteza Abyadeh, Masoumeh Zarei Kheirabadi, Pei-Chi Hou, Vedat Sari, Kyubin Lee, Rohil Hameed, Bushra Mehkri, Elizabeth Malaugh, Jason Newton, Tomasz Kordula and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Morteza AbyadehDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Masoumeh Zarei KheirabadiDepartment of Cellular, Molecular, and Genetic Medicine, School of Medicine and the Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Pei-Chi HouDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Vedat SariDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Kyubin LeeDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Rohil HameedDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Bushra MehkriDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Elizabeth MalaughSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA 23284, USA.
Jason NewtonSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA 23284, USA.
Tomasz KordulaDepartment of Cellular, Molecular, and Genetic Medicine, School of Medicine and the Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Yuh-Hwa WangDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Alaattin KayaDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.

Funding

New approach for cholesterol and sphingolipid reduction in Niemann-Pick C1 diseaseR00HD096117 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEWTON, JASON CHARLES · 2020 to 2022
$662k
NICHD NIH HHS R00 HD096117
6 · The paper itself

Abstract

Lysosomal dysfunction is a prominent feature of neurodegeneration and aging, yet how primary defects in lysosomal trafficking are converted into progressive cellular decline remains poorly understood. Niemann Pick disease type C (NPC), caused by impaired

Indexed as

AgingDNA damageFingolimodGeroprotectionNeuroinflammationNiemann–Pick disease type C

Identifiers

PMID42523504
PMCPMC13405409

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.