Evidence map›Paper›PMID 42523496›Full record

ArticleResearch square2026

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells.

Jason B Williams, Shishir M Pant, Alexander L Kley, Bharat A Rajmalani, Clarence Yapp, Jiang Zhang, Kyle Deans, Elizabeth Rotrosen, Angelika Sales, Peter K Sorger and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jason B WilliamsDermatology, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-8386-6285
Shishir M PantHarvard Medical School, Boston, MA.ORCID 0000-0002-2686-7898
Alexander L KleyDermatology, Brigham and Women's Hospital, Boston, MA.ORCID 0009-0003-8384-9674
Bharat A RajmalaniDermatology, Brigham and Women's Hospital, Boston, MA.
Clarence YappHarvard Medical School, Boston, MA.ORCID 0000-0003-1144-5710
Jiang ZhangDermatology, Brigham and Women's Hospital, Boston, MA.
Kyle DeansDermatology, Brigham and Women's Hospital, Boston, MA.
Elizabeth RotrosenDermatology, Brigham and Women's Hospital, Boston, MA.
Angelika SalesDepartment of Biosciences and Medical Biology, University of Salzburg, Salzburg, Austria.
Peter K SorgerHarvard Medical School, Boston, MA.ORCID 0000-0002-3364-1838
Thomas S KupperDermatology, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-4229-2916

Funding

DERMATOLOGY TRAINING GRANTT32AR007098 · NIAMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI THOMAS S. KUPPER · 1986 to 2026
$8.1M
Skin Homing T CellsR01AR065807 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUPPER, THOMAS S. · 2013 to 2022
$6.3M
Generation of Robust Resident Memory T cells in Barrier Tissues through Skin VaccinationR01AI127654 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN, KUPPER, THOMAS S. · 2017 to 2021
$6.0M
Skin vaccination and generation of protective lung-tropic memory T cellsR01AI175582 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI THOMAS S. KUPPER · 2024 to 2026
$2.8M
Using the IL-1R1 and its ligands to optimize the T cell immune response to cancerR01CA279457 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI THOMAS S. KUPPER · 2023 to 2026
$2.4M
NCI NIH HHS R01 CA279457NIAID NIH HHS R01 AI127654NIAID NIH HHS R01 AI175582NIAMS NIH HHS R01 AR065807NIAMS NIH HHS T32 AR007098
6 · The paper itself

Abstract

How the immune system surveys nascent tumors and how this surveillance is subverted remain poorly understood. Using high-plex cyclic immunofluorescence and 3D imaging, we identified regulatory T (Treg) cells that co-localize with tissue-resident memory (T

Identifiers

PMID42523496
PMCPMC13405490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.