Evidence map›Paper›PMID 42523480›Full record

ArticleResearch square2026

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine and reduced Alzheimer's disease risk.

Alison Goate, Carmen Romero-Molina, Ruben Gomez-Gutierrez, Wen Yi See, Tulsi Patel, Hayk Davtyan, Jiacheng Ma, Quanyun Xu, Michael Sewell, Kendra Allton and 8 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alison GoateIcahn School of Medicine at Mount Sinai.ORCID 0000-0002-0576-2472
Carmen Romero-MolinaIcahn School of Medicine at Mount Sinai.
Ruben Gomez-GutierrezThe Belfer Neurodegeneration Consortium.
Wen Yi SeeIcahn School of Medicine at Mount Sinai.
Tulsi PatelIcahn School of Medicine at Mount Sinai.ORCID 0000-0002-2797-1443
Hayk DavtyanUniversity of California Irvine.ORCID 0000-0001-8554-6456
Jiacheng MaThe Belfer Neurodegeneration Consortium.
Quanyun XuUniversity of Texas MD Anderson Cancer Center.
Kendra AlltonThe University of Texas M. D. Anderson Cancer Center.ORCID 0000-0002-4204-0807
Morgan McReynoldsThe Belfer Neurodegeneration Consortium.
Olivia CalderonThe Belfer Neurodegeneration Consortium.
Yaima LightfootThe Belfer Neurodegeneration Consortium.
Guido Bommerde Duve Institute, UCLouvain.ORCID 0000-0001-6898-4884
Carlos CruchagaWashington University School of Medicine.ORCID 0000-0002-0276-2899
Mathew Blurton-JonesUniversity of California, Irvine.ORCID 0000-0002-7770-7157
William RayThe University of Texas MD Anderson Cancer Center.ORCID 0000-0002-4491-167X
Edoardo MarcoraIcahn School of Medicine at Mount Sinai.ORCID 0000-0002-3829-4927

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI ALISON M GOATE · 2021 to 2026
$42.0M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
NCATS NIH HHS UL1 TR004419NCI NIH HHS P30 CA016672NIA NIH HHS U19 AG069701NIH HHS S10 OD026880NIH HHS S10 OD030463
6 · The paper itself

Abstract

Lactamase β (LACTB) is a serine β-lactamase-like mitochondrial enzyme genetically associated with obesity, kidney disease, and hyperlipidemia.

Indexed as

Alzheimer’s DiseaseimmunometabolismLACTBmicroglia

Identifiers

PMID42523480
PMCPMC13405478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.