ArticlebioRxiv : the preprint server for biology2026
Convergent Inhibitory Cortical Circuit Disruption Drives Genetically Distinct Absence Seizures.
Siyuan Song, Shu-Ning Natalie Lau, Doan Tran, Cecilia Ljungberg, Jianrong Tang, Qinglong Miao, Atul Maheshwari, Jeffrey L Noebels, Xiaolong Jiang
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Siyuan SongJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.
Shu-Ning Natalie LauJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.
Doan TranJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.
Cecilia LjungbergJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.
Jianrong TangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.
Atul MaheshwariDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Jeffrey L NoebelsDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Xiaolong JiangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.
Funding
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9MPLASTICITY IN DEVELOPING EPILEPTIC BRAINR01NS029709 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI NOEBELS, JEFFREY · 1991 to 2025
$9.1MDevelopment of aberrant cortical interneuron circuitry in genetic mouse models of absence epilepsyR01NS110767 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI JIANG, XIAOLONG, NOEBELS, JEFFREY · 2020 to 2024
$2.2MDeciphering the building blocks of the macaque prefrontal cortical microcircuitR01MH120404 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI JIANG, XIAOLONG · 2019 to 2023
$2.0MDeciphering the transcriptomic signatures, physiology, and connectivity of the specialized morphotypes in macaque insular cortexR01MH122169 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI JIANG, XIAOLONG · 2020 to 2024
$1.2MTecan EVO GenePaint robotS10OD016167 · OD · BAYLOR COLLEGE OF MEDICINE · PI LJUNGBERG, CECILIA · 2013 to 2013
$215kNICHD NIH HHS P50 HD103555NIH HHS S10 OD016167NIMH NIH HHS R01 MH120404NIMH NIH HHS R01 MH122169NINDS NIH HHS R01 NS029709NINDS NIH HHS R01 NS110767
6 · The paper itselfAbstract
Childhood absence epilepsy is one of the most common pediatric epilepsies, characterized by brief involuntary lapse in consciousness and generalized spike-wave discharges (SWDs) on EEG. Despite a growing list of causative genes, the core cortical circuit abnormalities driving this highly stereotyped SWD phenotype remain elusive. Using two well-established absence epilepsy mouse models carrying point mutations in distinct genes altering pre and postsynaptic transmission, stargazer (
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PMID42523478
PMCPMC13405405
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