Evidence map›Paper›PMID 42523468›Full record

ArticleResearch square2026

Distinctive properties of the prion protein in the brain and retina in the amyloidosis associated with the PRNP F198S Mutation.

Bernardino Ghetti, Bradley S Glazier, Michele Fiorini, Kathy L Newell, José M Bonnin, Jill R Murrell, Leah Rie Varner, Max Jacobsen, James F Striebel, Suzette A Priola and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Bernardino GhettiDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive MS A138, Indianapolis, Indiana 46202, USA.
Bradley S GlazierDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive MS A138, Indianapolis, Indiana 46202, USA.
Michele FioriniDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, L.A. Scuro, 10, Verona, 37134, Italy.
Kathy L NewellDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive MS A138, Indianapolis, Indiana 46202, USA.
José M BonninDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive MS A138, Indianapolis, Indiana 46202, USA.
Jill R MurrellDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive MS A138, Indianapolis, Indiana 46202, USA.
Leah Rie VarnerRocky Mountain Laboratories, Laboratory of Neurological Infections and Immunity, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Hamilton, MT USA.
Max JacobsenDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive MS A138, Indianapolis, Indiana 46202, USA.
James F StriebelRocky Mountain Laboratories, Laboratory of Neurological Infections and Immunity, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Hamilton, MT USA.
Suzette A PriolaRocky Mountain Laboratories, Laboratory of Neurological Infections and Immunity, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Hamilton, MT USA.
Gianluigi ZanussoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, L.A. Scuro, 10, Verona, 37134, Italy.

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's diseaseR01AG075802 · NIA · MAYO CLINIC JACKSONVILLE · PI BERNARDINO Francesco GHETTI, Lea Tenenholz Grinberg · 2022 to 2026
$15.5M
Structural analysis of tau associated with parenchymal and vascular prion protein amyloidosisR01AG071177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2024 to 2025
$1.5M
NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG071177NIA NIH HHS R01 AG075802
6 · The paper itself

Abstract

Prion protein (PrP) deposits in the form of diffuse and cored plaques occur in most gray matter areas of the brain of individuals affected by Gerstmann-Strässler-Scheinker disease (GSS) associated with the F198S mutation in

Indexed as

Gerstmann-Sträussler-Scheinker diseaseprionPRNP F198S mutationPRNP generetina

Identifiers

PMID42523468
PMCPMC13405482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.