Evidence map›Paper›PMID 42523453›Full record

ArticlebioRxiv : the preprint server for biology2026

Sustained loss of

Tessa M Lochetto, Thiago N Menezes, Kevin Cho, Srikar Vegesna, Michaela M Morhaus, Jeremie L A Ferey, Merima Forny, Leah P Shriver, Gretchen A Meyer, Gary J Patti and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tessa M LochettoDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-5668-0955
Thiago N MenezesDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Kevin ChoCenter for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-3041-3506
Srikar VegesnaDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Michaela M MorhausDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3077-2354
Jeremie L A FereyProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3382-2935
Merima FornyDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Leah P ShriverCenter for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-5673-0940
Gretchen A MeyerProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9268-3993
Gary J PattiCenter for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-3748-6193
Natalie M NiemiDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5174-4005

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Delineating phosphorylation-mediated regulation of mitochondrial functionR35GM151130 · NIGMS · WASHINGTON UNIVERSITY · PI Natalie Niemi · 2023 to 2026
$1.6M
NIAMS NIH HHS P30 AR074992NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIGMS NIH HHS R35 GM151130
6 · The paper itself

Abstract

The mitochondrial phosphatase PPTC7 is required to sustain mammalian metabolism, as its global knockout (KO) triggers hypoketotic hypoglycemia and perinatal lethality in mice. However, the extent to which the loss of

Identifiers

PMID42523453
PMCPMC13405280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.