Evidence map›Paper›PMID 42523417›Full record

ArticlebioRxiv : the preprint server for biology2026

Pathogen Subversion of Neuro-Epidermal Signaling Impairs Lysosomal Function to Disrupt Collagen Homeostasis.

Qian Li, Yating Liu, Hanyi Chen, Weilie Xiao, Bin Qi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Qian LiSchool of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases,Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, 650091,China.
Yating LiuSchool of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases,Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, 650091,China.
Hanyi ChenSchool of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases,Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, 650091,China.
Weilie XiaoSchool of Chemical Science and Technology, Key Laboratory of Medicinal Chemistry for Natural Resource - Ministry of Education, Yunnan University, Kunming, 650091, China.
Bin QiSchool of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases,Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, 650091,China.ORCID 0000-0003-2261-1550

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

The epidermis relies on collagen-rich extracellular matrices (ECMs) to maintain barrier integrity against pathogens. Lysosomes regulate cuticle collagen turnover, yet how neuronal signaling modulates epidermal lysosomal function and collagen organization during infection remains unclear. Using

Identifiers

PMID42523417
PMCPMC13405403

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.