Evidence map›Paper›PMID 42523398›Full record

ArticlebioRxiv : the preprint server for biology2026

Concurrent Stereotactic Body Radiation Therapy and KRAS Inhibition Synergistically Improve Pre-clinical Pancreatic Cancer Treatment.

Tianyu Wang, Liang Wang, Jiaqian Xu, Youming Guo, Ling Xia, Yuting Li, Fada Guan, Boyi Gan, David S Hong, Vincent Bernard and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianyu WangDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Liang WangDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jiaqian XuDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0009-0004-2094-4778
Youming GuoDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-6354-6671
Ling XiaDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yuting LiDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Fada GuanDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Boyi GanDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-8884-6040
David S HongDepartment of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Vincent BernardDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-1555-608X
Dadi JiangDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-0935-3908
Albert C KoongDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-9824-1643

Funding

Tumor hypoxia promotes acquired resistance to radiation through ferroptosis inhibitionU54CA274220 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Boyi Gan, ALBERT KOONG · 2022 to 2026
$8.4M
Targeting ferroptosis in cancer therapyR01CA269646 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Boyi Gan · 2023 to 2026
$2.0M
Targeting disulfidptosis in cancer: mechanisms and preclinical translationR01CA301148 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Boyi Gan · 2026 to 2026
$622k
NCI NIH HHS R01 CA269646NCI NIH HHS R01 CA301148NCI NIH HHS U54 CA274220
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most challenging cancers to treat due to the dismal survival rate, poor post-treatment outcome and profound resistance to a wide range of therapies. With mutant

Identifiers

PMID42523398
PMCPMC13404893

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.