Evidence map›Paper›PMID 42523394›Full record

ArticlebioRxiv : the preprint server for biology2026

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules.

Samuel Liu, Peng Xiao, Matthias Elgeti, Eve J Fine, Emilio Y Lucero, Mikkel Vestergaard, Junyan Wang, Arun Jyothidasan, Angus Li, Changxiu Qu and 19 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Samuel LiuDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Peng XiaoDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Matthias ElgetiInstitute for Drug Discovery and Institute for Medical Physics and Biophysics, Leipzig University Medical School, Leipzig, Germany.
Eve J FineDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Emilio Y LuceroDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Mikkel VestergaardAmgen Research Copenhagen, Copenhagen, Denmark.
Junyan WangDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Arun JyothidasanDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Angus LiDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Changxiu QuDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Eva OlsenAmgen Research Copenhagen, Copenhagen, Denmark.
Georgios MazisAmgen Research Copenhagen, Copenhagen, Denmark.
Josephine K MadsenAmgen Research Copenhagen, Copenhagen, Denmark.
Carl-Mikael SuomivuoriDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Jihee KimDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Natalia PakharukovaDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Rashad RahmanDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Stephanie M KereliukDepartment of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Walter J KochDepartment of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Ryan T StrachanPresent address: Septerna Inc., South San Francisco, CA 94080, USA.
Dean P StausDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Ali MasoudiDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Wayne L HubbellJules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Alem W KahsaiDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Ron O DrorDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Howard A RockmanDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Jin-Peng SunKey Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Shandong, China.
Seungkirl AhnDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Robert J LefkowitzDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

Funding

Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI John William Elrod · 2017 to 2026
$21.0M
Molecular Regulation of Cardiovascular 7 TM ReceptorsR01HL016037 · NHLBI · DUKE UNIVERSITY · PI ROBERT J LEFKOWITZ · 1985 to 2026
$14.5M
MECHANISMS OF MALADAPTATION IN HEART FAILURER01HL056687 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI Howard A Rockman · 1996 to 2026
$12.3M
Stanford ChEM-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM139791 · NIGMS · STANFORD UNIVERSITY · PI Carolyn Bertozzi, Christine Jacobs-Wagner · 2021 to 2026
$2.4M
Discovering the mechanism of GPCR-mediated arrestin stimulation to enable effective drug therapiesR01GM127359 · NIGMS · STANFORD UNIVERSITY · PI DROR, RON · 2018 to 2022
$1.5M
NHLBI NIH HHS P01 HL134608NHLBI NIH HHS R01 HL016037NHLBI NIH HHS R01 HL056687NIGMS NIH HHS R01 GM127359NIGMS NIH HHS T32 GM139791
6 · The paper itself

Abstract

Blockade of signaling through the angiotensin II type 1 receptor (AT1R), a prototypical G protein-coupled receptor (GPCR), by angiotensin receptor blockers (ARBs) is a major therapeutic approach to treating a wide variety of cardiovascular and renal diseases

Identifiers

PMID42523394
PMCPMC13405261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.