Evidence map›Paper›PMID 42523386›Full record

ArticlebioRxiv : the preprint server for biology2026

Sex-specific developmental phenotypes and their response to neonatal

Alyssa Duerst, Laura Hawley, Linnea Johnson, Zaina Obeid, Laura Snellenberger, Drew Folz, Charles R Goodlett, Randall J Roper

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alyssa DuerstDepartment of Biology, Indiana University Indianapolis, 723 W Michigan Street, SL306, Indianapolis, IN 46202, USA.
Laura HawleyDepartment of Biology, Indiana University Indianapolis, 723 W Michigan Street, SL306, Indianapolis, IN 46202, USA.
Linnea JohnsonDepartment of Biology, Indiana University Indianapolis, 723 W Michigan Street, SL306, Indianapolis, IN 46202, USA.
Zaina ObeidDepartment of Biology, Indiana University Indianapolis, 723 W Michigan Street, SL306, Indianapolis, IN 46202, USA.
Laura SnellenbergerDepartment of Biology, Indiana University Indianapolis, 723 W Michigan Street, SL306, Indianapolis, IN 46202, USA.
Drew FolzDepartment of Biology, Indiana University Indianapolis, 723 W Michigan Street, SL306, Indianapolis, IN 46202, USA.
Charles R GoodlettDepartment of Psychology, Indiana University Indianapolis, 402 N Blackford St, LD124, Indianapolis, IN 46202, USA.
Randall J RoperDepartment of Biology, Indiana University Indianapolis, 723 W Michigan Street, SL306, Indianapolis, IN 46202, USA.ORCID 0000-0002-9860-5037

Funding

Strategies for treatment of Down syndrome: Identifying age- and sex-specific developmental windows using inducible genetic reduction of Dyrk1aR01AR078663 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GOODLETT, CHARLES R., ROPER, RANDALL J · 2020 to 2020
$1.9M
NIAMS NIH HHS R01 AR078663
6 · The paper itself

Abstract

Children with Down syndrome (DS) experience delays in cognitive, physical, and motor development. Overexpression of

Indexed as

behaviordevelopmentDyrk1asex differencesTrisomy 21

Identifiers

PMID42523386
PMCPMC13405145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.