Evidence map›Paper›PMID 42523377›Full record

ArticlebioRxiv : the preprint server for biology2026

Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD.

Arnar Breevoort, Dimitar Ivanov, Liam Horan-Portelance, Alissa Nana, Sarat Vatsavayai, Àlex Tudoras Miravet, Jenelle L Wallace, Jingwen W Ding, Felipe L Pereira, Kristen Fernhoff and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Arnar BreevoortEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8929-9138
Dimitar IvanovDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Liam Horan-PortelanceFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.ORCID 0000-0002-7237-7574
Alissa NanaFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.ORCID 0000-0003-3474-8044
Sarat VatsavayaiFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
Àlex Tudoras MiravetFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
Jenelle L WallaceEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Jingwen W DingEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Felipe L PereiraFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
Kristen FernhoffFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
Maria Luisa Gorno-TempiniDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Salvatore SpinaFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
Jennifer S YokoyamaFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
Howard J RosenDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Lea T GrinbergDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Frank M J JacobsUniversity of Amsterdam, Swammerdam Institute for Life Sciences, Amsterdam, the Netherlands.
Bruce L MillerDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
William W SeeleyFein Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.ORCID 0000-0003-1410-2027
Alex A PollenEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3263-8634

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Adam Mark Staffaroni · 2019 to 2026
$120.9M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Early Onset Alzheimer's Disease ConsortiumR56AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2017 to 2017
$7.7M
Deep Pathological Phenotyping in Frontotemporal Dementia and Motor Neuron Disease.R01NS104437 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEELEY, WILLIAM W · 2018 to 2022
$4.3M
Human‐specific vulnerabilities and compensatory adaptations to age‐related stressors in selectively vulnerable midbrain dopaminergic neuronsR01AG087959 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATHERINE S. POLLARD, ALEXANDER A POLLEN · 2024 to 2026
$4.2M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG087959NIA NIH HHS R56 AG057195NIA NIH HHS U01 AG057195NIA NIH HHS U19 AG063911NIH HHS S10 OD028511NINDS NIH HHS R01 NS104437
6 · The paper itself

Abstract

Frontotemporal dementia (FTD) is characterized by selective neuronal vulnerability, yet the features that predispose specific neuron types to degeneration remain unclear. We performed single-nucleus RNA sequencing of frontoinsular cortex, a region affected early in behavioral variant FTD, across individuals with

Indexed as

amyotrophic lateral sclerosisfrontoinsular cortexfrontotemporal dementiaselective vulnerabilitySingle-cellsingle-nucleusTDP-43von Economo neurons

Identifiers

PMID42523377
PMCPMC13405016

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.