Evidence map›Paper›PMID 42523369›Full record

ArticlebioRxiv : the preprint server for biology2026

Intermolecular disulfide bond formation promotes Hsp42 higher-order assembly and shapes client selection in yeast.

Long Duy Duong, Daniel Escobar-Osorio, Alexander B Saltzman, Kevin A Morano

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Long Duy DuongDepartment of Microbiology and Molecular Genetics, McGovern Medical School at UTHealth Houston, Houston, TX USA.ORCID 0000-0001-6016-9682
Daniel Escobar-OsorioDepartment of Microbiology and Molecular Genetics, McGovern Medical School at UTHealth Houston, Houston, TX USA.ORCID 0009-0004-6520-5151
Alexander B SaltzmanMass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX USA.ORCID 0000-0003-4166-9555
Kevin A MoranoDepartment of Microbiology and Molecular Genetics, McGovern Medical School at UTHealth Houston, Houston, TX USA.ORCID 0000-0002-5992-0253

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Chaperone-mediated mechanisms of cellular proteostasisR35GM149196 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KEVIN ANTHONY MORANO · 2023 to 2026
$1.5M
NCI NIH HHS P30 CA125123NIGMS NIH HHS R35 GM149196
6 · The paper itself

Abstract

Cellular redox homeostasis plays a critical role in regulating protein function, including chaperone activity, through reversible oxidation of cysteine and methionine residues. Previously, we found that budding yeast cells experiencing redox imbalance due to inactivated thioredoxin reductase (

Indexed as

disulfide bondmitochondrial importredoxsequestrasesHSPyeast

Identifiers

PMID42523369
PMCPMC13405057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.