Evidence map›Paper›PMID 42523358›Full record

ArticlebioRxiv : the preprint server for biology2026

When Music Loses Its Pleasure: Hippocampal Cingulum White Matter as a Structural Mediator of Musical Reward Decline in Aging.

Jinyu Wang, Nicholas Kathios, Benjamin Kubit, Kelsie Lopez, Ji Chul Kim, Edward Large, Stephanie Noble, Psyche Loui

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinyu WangDepartment of Interdisciplinary Studies - Arts/Media, Northeastern University.ORCID 0000-0002-6940-4703
Nicholas KathiosDepartment of Psychology, Northeastern University.ORCID 0000-0002-7550-767X
Benjamin KubitDepartment of Music, Northeastern University.ORCID 0000-0003-0940-9526
Kelsie LopezDepartment of Psychology, Northeastern University.ORCID 0000-0002-4046-4649
Ji Chul KimDepartment of Psychological Sciences, University of Connecticut.ORCID 0000-0002-8909-3340
Edward LargeDepartment of Psychological Sciences, University of Connecticut.ORCID 0000-0003-3909-3518
Stephanie NobleDepartment of Psychology, Northeastern University.ORCID 0000-0002-4804-5553
Psyche LouiDepartment of Music, Northeastern University.ORCID 0000-0001-7664-6092

Funding

Gamma-Music Based Intervention for Mild Alzheimer's DiseaseR01AG078376 · NIA · NORTHEASTERN UNIVERSITY · PI Edward W Large, Psyche Loui · 2022 to 2026
$2.7M
SynG: a Music-Based Intervention for Alzheimer's and Mild Cognitive ImpairmentR43AG092067 · NIA · OSCILLOSCAPE, LLC · PI LARGE, EDWARD W, LOUI, PSYCHE · 2025 to 2025
$468k
NIA NIH HHS R01 AG078376NIA NIH HHS R43 AG092067
6 · The paper itself

Abstract

Individuals' ability to obtain pleasure from music, referred to as musical reward sensitivity, declines with age, yet the neural mechanisms underlying this decline remain unclear. In this study, we investigated musical reward sensitivity measured in 58 older adults and 131 young adults. Consistent with prior findings, young adults reported higher musical reward sensitivity than older adults (

Indexed as

agingdiffusion tensor imagingmachine learningmediation analysismusical reward sensitivitywhite matter

Identifiers

PMID42523358
PMCPMC13405128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.