Evidence map›Paper›PMID 42523333›Full record

ArticlebioRxiv : the preprint server for biology2026

BR-bodies link RNA homeostasis to stress tolerance and intracellular fitness in

Kaveendya S Mallikaarachchi, Rosemary Northcote, Thomas Kim, Melene A Alakavuklar, Vincent Lawal, Vidhyadhar Nandana, Aretha Fiebig, Jared M Schrader, Sean Crosson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kaveendya S MallikaarachchiDepartment of Biology, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-5201-2279
Rosemary NorthcoteDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0009-0002-7780-6355
Thomas KimDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0009-0000-4930-5401
Melene A AlakavuklarDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0003-4067-6331
Vincent LawalDepartment of Biology, Indiana University, Bloomington, IN, USA.ORCID 0000-0001-9609-2701
Vidhyadhar NandanaDepartment of Biological Sciences, Wayne State University, Detroit, MI, USA.
Aretha FiebigDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-0612-5029
Jared M SchraderDepartment of Biology, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-5728-5882
Sean CrossonDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-1727-322X

Funding

Mechanisms of Non-Shine-Dalgarno Translation InitiationR35GM124733 · NIGMS · WAYNE STATE UNIVERSITY · PI Jared Michael Schrader · 2017 to 2026
$3.6M
Molecular mechanisms controlling stress responses and cell adhesion in bacteriaR35GM131762 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Sean Crosson · 2019 to 2026
$3.2M
Regulation of the Brucella abortus general stress responseR01AI177619 · NIAID · MICHIGAN STATE UNIVERSITY · PI Sean Crosson · 2024 to 2026
$1.5M
Functional analysis of a novel cell envelope integrity protein in Brucella ovisF32AI174818 · NIAID · MICHIGAN STATE UNIVERSITY · PI ALAKAVUKLAR, MELENE · 2023 to 2025
$221k
NIAID NIH HHS F32 AI174818NIAID NIH HHS R01 AI177619NIGMS NIH HHS R35 GM124733NIGMS NIH HHS R35 GM131762
6 · The paper itself

Abstract

Bacterial gene expression depends on the coordinated regulation of RNA synthesis, processing, and decay. The conserved RNA degradosome scaffold, Ribonuclease E (RNase E), assembles into phase-separated bacterial ribonucleoprotein bodies (BR-bodies) through its C-terminal intrinsically disordered region (IDR). This IDR also scaffolds recruitment of degradosome client proteins that carry out post-transcriptional gene regulation. Whether BR-bodies regulate virulence programs to support infection, however, is largely undefined. We show that RNase E of the intracellular pathogen

Identifiers

PMID42523333
PMCPMC13405055

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.