ArticlebioRxiv : the preprint server for biology2026
α-Synuclein pathology differentially alters T-type calcium currents in vulnerable and resilient substantia nigra dopaminergic subpopulations.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Aggregation of α-synuclein protein is a characteristic of Parkinson's disease pathology that relates to the degeneration of vulnerable dopaminergic neurons and motor symptoms of the disease. However, α-synuclein pathology can contribute to neuronal dysfunction by disrupting several processes within the cell, including intracellular calcium balance, mitochondrial function, and synaptic function. Here, we use a preformed fibril (PFF) model of synucleinopathy to examine effects of striatal α-synuclein seeding on dopamine neurons of the substantia nigra
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