Evidence map›Paper›PMID 42523317›Full record

ArticlebioRxiv : the preprint server for biology2026

piRNA loss unleashes episodic transposition bursts.

Peiwei Chen, Peiyu Xu, Hamna Waseem, John McCormick, Katherine C Pan, Alexei A Aravin, Andrew G Clark, Cédric Feschotte

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peiwei ChenDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-7160-6673
Peiyu XuDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Hamna WaseemDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
John McCormickDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Katherine C PanHarvard-MIT Program in Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
Alexei A AravinDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-6956-8257
Andrew G ClarkDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-7159-8511
Cédric FeschotteDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-8772-6976

Funding

TAKASHIMA DIVERSITY SUPPLEMENT TO: REGULATION OF GAMETE USE AND NEURAL PATHWAYS IN REPRODUCTIONR01HD059060 · NICHD · CORNELL UNIVERSITY · PI ANDREW G CLARK, Mariana Federica Wolfner · 2009 to 2026
$5.8M
Genomic and Physiological Impact of Transposable Elements.R35GM122550 · NIGMS · CORNELL UNIVERSITY · PI Cedric Feschotte · 2017 to 2026
$4.4M
Molecular Mechanism of the piRNA BiogenesisR01GM097363 · NIGMS · CORNELL UNIVERSITY · PI ARAVIN, ALEXEI A. · 2011 to 2025
$4.0M
NICHD NIH HHS R01 HD059060NIGMS NIH HHS R01 GM097363NIGMS NIH HHS R35 GM122550
6 · The paper itself

Abstract

In Metazoa, transposon expression is suppressed by the piRNA pathway, and disruption of this pathway leads to rampant transposon expression. However, it remains unclear whether increased transposon expression results in actual transposition, and if so, which and how frequently transposons mobilize upon piRNA loss. Here, we developed a framework to track transposon copy accumulation across generations on a single set of nonrecombining haploid genome in the

Identifiers

PMID42523317
PMCPMC13404956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.