Evidence map›Paper›PMID 42523300›Full record

ArticlebioRxiv : the preprint server for biology2026

Aquaporin-4 mislocalization from astrocyte endfeet prolongs survival in a prion-cerebral amyloid angiopathy model.

Samantha Flores, Amanda Wilpitz, Daniel Ojeda-Juarez, Jin Wang, Garrett Danque, Paige Sumowski, Gail Funk, Adela Malik, Don Pizzo, Emily Richards and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samantha FloresDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Amanda WilpitzDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Daniel Ojeda-JuarezDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Jin WangDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Garrett DanqueDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Paige SumowskiDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Gail FunkDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Adela MalikDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Don PizzoDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Emily RichardsDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Jeffrey J IliffDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Christina J SigurdsonDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.

Funding

Mechanisms of Prion Aggregation and Species BarriersR01NS069566 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D, RAVITS, JOHN · 2011 to 2025
$5.7M
Mechanisms of Prion SpreadR01NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2012 to 2021
$3.4M
Mechanisms of Prion Spread and Neuronal ToxicityR37NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christina Sigurdson · 2023 to 2026
$2.6M
Multidisciplinary training in basic and translational Alzheimer's disease researchT32AG066596 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 2020 to 2024
$2.2M
Molecular basis of spongiform encephalopathy in prion diseaseR21NS105498 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2018 to 2019
$432k
NIA NIH HHS T32 AG066596NINDS NIH HHS R01 NS069566NINDS NIH HHS R01 NS076896NINDS NIH HHS R21 NS105498NINDS NIH HHS R37 NS076896
6 · The paper itself

Abstract

Aquaporin 4 (AQP4) water channels are polarized to astrocytic endfeet at blood vessel interfaces, and lose polarity in vascular diseases, including stroke, chronic traumatic encephalopathy, and Alzheimer's disease. AQP4 modulates water influx and efflux in the interstitial fluid, yet how AQP4 localization impacts cerebral amyloid angiopathy (CAA) remains poorly understood. Here we show that astrocytic end feet and AQP4 are displaced from amyloid-bearing vessels in a prion-CAA mouse model that expresses GPI-anchorless PrP

Indexed as

CAAglymphaticneurodegenerative diseaseneuroinflammationprion diseaseprotein clearanceprotein misfoldingvascular disease

Identifiers

PMID42523300
PMCPMC13404806

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.