Evidence map›Paper›PMID 42523289›Full record

ArticlebioRxiv : the preprint server for biology2026

Genetically distinct microenvironment determines cancer survival and response to therapy in mice.

Mark A Warner, Jennifer K Sargent, Shawnna R Farley, Beth L Dumont, Muneer G Hasham

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark A WarnerXenograft and Live Imaging Services, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609.ORCID 0000-0001-8506-3518
Jennifer K SargentXenograft and Live Imaging Services, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609.ORCID 0009-0006-0014-3791
Shawnna R FarleyXenograft and Live Imaging Services, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609.
Beth L DumontXenograft and Live Imaging Services, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609.ORCID 0000-0003-0918-0389
Muneer G HashamXenograft and Live Imaging Services, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609.ORCID 0000-0002-4498-0210

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
Impact of Genetic Diversity on Human Xenograft Tumor GrowthR33CA247669 · NCI · JACKSON LABORATORY · PI HASHAM, MUNEER GULAMHUSEIN · 2020 to 2022
$1.3M
NCI NIH HHS P30 CA034196NCI NIH HHS R33 CA247669
6 · The paper itself

Abstract

Genetic uniqueness of the tumor microenvironment significantly influences cancer growth, survival, and response to therapy, independent of the cancer cell's intrinsic properties or the adaptive immune system. Using genetically distinct

Indexed as

cancergenetic diversitypreclinicaltumor microenvironmentxenograft

Identifiers

PMID42523289
PMCPMC13404881

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.