Evidence map›Paper›PMID 42523286›Full record

ArticlebioRxiv : the preprint server for biology2026

A Role for Astrocyte Metabolism in Species-Specific Neuronal Development.

Sheila Steiner, Kaia Foster, Rebecca Chinn, Joshua Pratt, Sarah Fernandes, Amandeep Sharma, Renata Santos, Christian Metallo, Maria Carolina Marchetto, Fred H Gage

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sheila SteinerDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-0277-4280
Kaia FosterDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0005-3189-9375
Rebecca ChinnMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-2768-8058
Joshua PrattLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Sarah FernandesLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Amandeep SharmaLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Renata SantosUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Signaling Mechanisms in Neurological Disorders, 75014 Paris, France.
Christian MetalloMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-2404-3040
Maria Carolina MarchettoDepartment of Anthropology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0449-9051
Fred H GageDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI JODI A LAPIDUS · 2004 to 2026
$102.6M
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
Project 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapyP01AG073084 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PETER D. ADAMS, GERALD SHADEL · 2021 to 2026
$13.6M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
Age-equivalent neurons from MCI patients to investigate early determinants of ADR01AG085634 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jerome S. Mertens · 2024 to 2026
$2.3M
Multidisciplinary training in basic and translational Alzheimer's disease researchT32AG066596 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 2020 to 2024
$2.2M
A high-resolution tribrid mass spectrometer to amplify bioanalytical capacity at Salk Institute Mass Spectrometry coreS10OD038262 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI METALLO, CHRISTIAN MICHAEL · 2025 to 2025
$1.2M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
A Hybrid Quadrupole-Orbitrap LC/MSS10OD021815 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SAGHATELIAN, ALAN · 2016 to 2016
$580k
NCI NIH HHS P30 CA014195NIA NIH HHS P01 AG073084NIA NIH HHS P30 AG068635NIA NIH HHS R01 AG085634NIA NIH HHS T32 AG066596NIA NIH HHS U19 AG023122NIH HHS S10 OD021815NIH HHS S10 OD026929NIH HHS S10 OD038262
6 · The paper itself

Abstract

Human neurons develop more slowly than non-human primate (NHP) neurons, a phenomenon called neoteny, but research has primarily focused on neuron-intrinsic drivers. We hoped to further elucidate any species-specific divergence in function and the astrocytes' role in influencing species-specific neurodevelopment rate. In this study, we identified a delayed onset of gliogenesis in human versus NHP organoid models. Transcriptomic and

Identifiers

PMID42523286
PMCPMC13404748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.