Evidence map›Paper›PMID 42523281›Full record

ArticlebioRxiv : the preprint server for biology2026

ITPKB is a conserved regulator of natural killer cell desensitization/education that constrains antitumor immunity.

Yeara Jo, Alexandros Karampatzakis, Seung Won Lee, Alice Peng, Zaina Ghouri, Monsserratt Moya, Elizabeth Andrews, Harrison Sudholz, Chenyu Zhang, Berna Bou Tayeh and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yeara JoDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-1340-1968
Alexandros KarampatzakisDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Seung Won LeeDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Alice PengDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Zaina GhouriDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Monsserratt MoyaDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Elizabeth AndrewsDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Harrison SudholzDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0009-0000-6848-4230
Chenyu ZhangDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-3199-9422
Berna Bou TayehLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0009-0002-3565-8905
Alejandro N MedinaDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Jiucheng DingDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0009-0003-9734-7528
Robert A SaxtonDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-9777-8270
Ziyang ZhangDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Yang ShiLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Hideho OkadaDepartment of Neurological Surgery at University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0076-9920
David H RauletDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-1257-8649

Funding

Mechanisms underlying combination therapy mobilizing NK cellsR01CA270790 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAVID H RAULET · 2022 to 2026
$2.3M
Tregulatory cell-mediated suppression of tumor elimination by NK cells and CD4 T cellsR01CA303968 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michel DuPage, DAVID H RAULET · 2025 to 2026
$1.3M
Preclinical development of breakthrough immunotherapy for brain tumorsR35NS142982 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Hideho Okada · 2026 to 2026
$943k
Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600k
NCI NIH HHS R01 CA270790NCI NIH HHS R01 CA303968NIH HHS S10 OD018174NINDS NIH HHS R35 NS142982
6 · The paper itself

Abstract

Natural Killer (NK) cell desensitization induced by persistent stimulation limits durable antitumor immunity, yet the molecular mechanisms governing this dysfunctional state remain poorly defined. To identify conserved regulators of NK cell desensitization, we performed comparative transcriptomic analyses across multiple murine models of persistent activation and dysfunction. This approach defined a shared transcriptional program of desensitization and identified

Identifiers

PMID42523281
PMCPMC13404888

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.