Evidence map›Paper›PMID 42523240›Full record

ArticlebioRxiv : the preprint server for biology2026

A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies.

Magdalena Riedl Khursigara, Alissa C Goss, Maria Kost-Alimova, Keith Keller, Christine Danielle De Mata, Ranjithmenon Muraleedharan, Edward Ryan Collantes, Matthew Brown, Elizabeth Grinkevich, Felichi Mae Arines and 40 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Magdalena Riedl KhursigaraBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Alissa C GossBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Maria Kost-AlimovaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Keith KellerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Christine Danielle De MataBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ranjithmenon MuraleedharanBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Edward Ryan CollantesBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Matthew BrownBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Elizabeth GrinkevichBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Felichi Mae ArinesBroad Institute of MIT and Harvard, Cambridge, MA, USA.
John LinBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Patrick ByrneBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Silvana Bazua ValentiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Elizabeth MoriciBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Julie RoignotBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jason ZavrasBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Brianna R SilvermanBroad Institute of MIT and Harvard, Cambridge, MA, USA.
John Carlos IgnacioBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yoochan MyungBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Seulki KwonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Andrew NelsonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Hyery YooBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Michelle MelansonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Matthew RacetteBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Valeria PadovanoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Seth L AlperBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Dominique CareyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Namrata D UdeshiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Moran Dvela-LevittThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Toshio NarimatsuBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Gustavo SakunoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Victor San Martin Carvalho CorreaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Nikolaos E EfstathiouBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Dimitrios P NtentakisBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Tian CaoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Zhiqian DongGavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA.
Kim Thien NguyenGavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA.
Carolline Rodrigues MenezesGavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA.
Ravi KurumbailBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Steven KazmirskiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Le XiaoDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
David LiuBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sumaiya IqbalBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Eric S LanderBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Demetrios G VavvasRetina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Krzysztof PalczewskiGavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA.
Juan Lorenzo B PabloBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Anna GrekaBroad Institute of MIT and Harvard, Cambridge, MA, USA.

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Molecular, Cellular, & Developmental Dynamics PhD ProgramT32GM007226 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI VAN VACTOR, DAVID L. · 1985 to 2021
$14.4M
MICROSCALED PROTEOGENOMICS FOR CANCER CLINICAL TRIALSU01CA214125 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ANURAG, MEENAKSHI, CARR, STEVEN A · 2017 to 2021
$7.0M
Center of Excellence for High Throughput Proteogenomic CharacterizationU24CA210986 · NCI · BROAD INSTITUTE, INC. · PI CARR, STEVEN A, GILLETTE, MICHAEL A · 2016 to 2020
$6.4M
Molecular mechanisms of podocyte injury in FSGSR01DK095045 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Anna Greka, Juan Lorenzo Pablo · 2014 to 2026
$5.1M
Role of TRPC5 channel inhibition in the treatment of glomerular diseaseR01DK099465 · NIDDK · BROAD INSTITUTE, INC. · PI Anna Greka · 2014 to 2026
$5.1M
Investigation of the role of TMED9 in the accumulation of a mutant protein in MUC1 kidney disease (MKD)F30DK127546 · NIDDK · HARVARD MEDICAL SCHOOL · PI GOSS, ALISSA CAMPBELL · 2020 to 2023
$173k
NCI NIH HHS U01 CA214125NCI NIH HHS U24 CA210986NIDDK NIH HHS F30 DK127546NIDDK NIH HHS R01 DK095045NIDDK NIH HHS R01 DK099465NIGMS NIH HHS T32 GM007226NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

Severe proteinopathies-such as retinitis pigmentosa, a form of inherited blindness-are driven by genetic mutations that overwhelm the quality control of the post-endoplasmic reticulum (post-ER) secretory pathway, causing toxic protein accumulation. Here, we identify a therapeutic node defined by a hetero-oligomeric cargo receptor complex consisting of TMED7, 2, 9, and 10. This "entrapment complex" anchors structurally and functionally diverse mutant clients within the early secretory pathway via TMED7 binding to the integral Golgi protein GRASP55. Disruption of the entrapment complex results in the clearance of accumulated protein cargoes.

Identifiers

PMID42523240
PMCPMC13404660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.