Evidence map›Paper›PMID 42523238›Full record

ArticlebioRxiv : the preprint server for biology2026

The basal cell state maintains pancreatic cancers by controlling an immunosuppressive circuit.

Anupriya Singhal, Kate Ryan, Samuel A Rose, Hannah C Styers, Jung Yun Kim, Nikhita Pasnuri, Ashlyn Moore, Jose Meza-Llamosas, Emma Chen, Josephine Adams and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Anupriya SinghalCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Kate RyanCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Samuel A RoseComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Hannah C StyersCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jung Yun KimCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nikhita PasnuriComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Ashlyn MooreCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jose Meza-LlamosasComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Emma ChenComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Josephine AdamsComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Ananya NandulaComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Roshan SharmaComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Zhuxuan LiCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Tal NawyComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Yan YanCurrent address: College of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Nuray TezcanDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Olca BasturkDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mara H ShermanCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Dana Pe'erComputational & Systems Biology Program, Sloan Kettering Institute, New York, New York, USA.
Tuomas TammelaCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
The Center for Tumor-Immune Systems Biology at MSKCCU54CA274492 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Dana Pe'er · 2022 to 2026
$16.3M
Total Neoadjuvant Therapy (TNT) for Borderline Resectable and Locally Advanced Pancreatic AdenocarcinomaP50CA257881 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Christine A Iacobuzio-Donahue · 2022 to 2026
$14.3M
MSK Paul Calabresi Career Development Award for Clinical OncologyK12CA184746 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Omar Abdel-Wahab, Simon N. Powell · 2015 to 2026
$8.3M
Targeting stem-like cells and their niche in pancreatic cancerR37CA244911 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Tuomas Tammela · 2020 to 2026
$3.4M
Mechanisms of p53 Engagement and Action at the Benign-to-Malignant Transition in Sporadic TumorigenesisR01CA283378 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SCOTT W. LOWE, Dana Pe'er · 2023 to 2026
$2.9M
NCI NIH HHS K12 CA184746NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA257881NCI NIH HHS R01 CA283378NCI NIH HHS R37 CA244911NCI NIH HHS U54 CA274492
6 · The paper itself

Abstract

Intra-tumoral heterogeneity is a cardinal feature of solid tumors, yet how distinct cancer cell states functionally contribute to malignant and stromal diversity

Identifiers

PMID42523238
PMCPMC13404871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.