Evidence map›Paper›PMID 42523234›Full record

ArticlebioRxiv : the preprint server for biology2026

A hierarchy of spatial confinements governs chromatin dynamics and genomic encounters.

Megan Aubrey, Arpita Prusy, Olga K Dudko, Cornelis Murre

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Megan AubreyDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-5448-2960
Arpita PrusyDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA 92093.
Olga K DudkoDepartment of Physics, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-8944-8538
Cornelis MurreDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0003-2437-507X

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
The 3D-Structures of the Immunoglobulin Heavy Chain LocusR01AI082850 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRE, CORNELIS · 2009 to 2024
$5.4M
Elyra 7 Microscope with Lattice SIM2S10OD030505 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHENG, BINHAI · 2022 to 2022
$600k
Mechanisms that underpin immunoglobulin gene rearrangementR21AI193549 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRE, CORNELIS · 2025 to 2025
$439k
NIAID NIH HHS R01 AI082850NIAID NIH HHS R21 AI193549NIH HHS S10 OD030505NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Antibody diversity is generated through stochastic rearrangement of the immunoglobulin heavy chain locus (Igh) involving the recombination of variable (V

Indexed as

anomalous diffusionchromatin motionfirst passage timeGenome organizationloop extrusionnon-coding transcriptionnuclear condensates

Identifiers

PMID42523234
PMCPMC13404736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.