Evidence map›Paper›PMID 42523229›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural Determinants of Catalytic Bias in an AMP-Forming Acetyl-CoA Synthetase from

Selena Yaghoubi, David M Dinh, Leonard M Thomas, Neil Q Wofford, Michael J McInerney, Elizabeth A Karr

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Selena YaghoubiSchool of Biological Sciences, University of Oklahoma, Norman, OK 73019, USA.ORCID 0009-0006-9980-6902
David M DinhSchool of Biological Sciences, University of Oklahoma, Norman, OK 73019, USA.
Leonard M ThomasDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.ORCID 0000-0003-3920-0619
Neil Q WoffordSchool of Biological Sciences, University of Oklahoma, Norman, OK 73019, USA.
Michael J McInerneySchool of Biological Sciences, University of Oklahoma, Norman, OK 73019, USA.ORCID 0000-0002-8054-1389
Elizabeth A KarrSchool of Biological Sciences, University of Oklahoma, Norman, OK 73019, USA.ORCID 0000-0003-1200-4028

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Structure-Function Studies of MsvR, a Methanogen-Specific Transcriptional RegulaP20GM103640 · NIGMS · UNIVERSITY OF OKLAHOMA · PI THOMAS, LEONARD M · 2012 to 2021
$20.4M
Protein Production and Characterization CoreP30GM145423 · NIGMS · UNIVERSITY OF OKLAHOMA · PI ANN H WEST · 2022 to 2026
$6.9M
NIGMS NIH HHS P20 GM103640NIGMS NIH HHS P30 GM133894NIGMS NIH HHS P30 GM145423
6 · The paper itself

Abstract

Acetyl-coenzyme A (CoA) is a central metabolic intermediate that links carbon and energy metabolism across all domains of life. The interconversion of acetate and acetyl-CoA is carried out by three enzyme pathways: acetate kinase/phosphotransacetylase, ADP-forming acetyl-CoA synthetase, and AMP-forming acetyl-CoA synthetase (Acs). Acs enzymes serve critical physiological roles across diverse organisms by catalyzing a reversible two-step reaction forming acetyl-CoA and AMP from acetate and ATP. Isolated from the wastewater reclamation facility in Norman, Oklahoma,

Identifiers

PMID42523229
PMCPMC13404658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.