Evidence map›Paper›PMID 42523217›Full record

ArticlebioRxiv : the preprint server for biology2026

Selectivity for high-level language processing is highly localized in individual brains.

Rebecca M Belisle, Terri L Scott, Tyler K Perrachione

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rebecca M BelisleGraduate Program for Neuroscience, Boston University, Boston, Massachusetts, USA.ORCID 0000-0003-0701-1442
Terri L ScottDepartment of Psychology, Northeastern University, Oakland, California, USA.ORCID 0000-0001-9205-8581
Tyler K PerrachioneDepartment of Speech, Language & Hearing Sciences, Boston University, Boston, Massachusetts, USA.ORCID 0000-0002-9149-1815

Funding

Training in computational neuroscience: Integrating experiment, theory, and technology - T90 extensionT90DA032484 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SHINN-CUNNINGHAM, BARBARA · 2011 to 2016
$815k
Neural bases of phonological working memory in developmental language disordersR03DC014045 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PERRACHIONE, TYLER · 2015 to 2017
$491k
Neural dynamics of speech encoding and maintenance during phonological working memoryF32DC019531 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCOTT, TERRI LYNN · 2021 to 2023
$202k
Cortical development and neuroanatomical anomalies in developmental dyslexiaR03HD096098 · NICHD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PERRACHIONE, TYLER · 2018 to 2019
$165k
Structure-function correspondence in the cortical organization of languageF31DC022801 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Rebecca Michele Belisle · 2025 to 2026
$100k
NICHD NIH HHS R03 HD096098NIDA NIH HHS T90 DA032484NIDCD NIH HHS F31 DC022801NIDCD NIH HHS F32 DC019531NIDCD NIH HHS R03 DC014045
6 · The paper itself

Abstract

Some aspects of human behavior and cognition depend on focal and selective cortical areas, such as the frontal eye fields or fusiform face area, while others, like semantic knowledge, are broadly distributed across the cortex. Whether higher-level cognitive functions like language can also be highly localized has been a longstanding matter of debate. Here, we provide multiple lines of evidence that receptive language in the brain is subserved by a network of discrete, focal, and uniquely language-selective areas when examining individual brains. Using precision neuroimaging, we observed highly circumscribed patches of cortex that are distinctly selective for language, uniquely consistent in their response properties during language processing, and highly reliable in their anatomical locations within individuals (though variable in location across individuals). These findings indicate that language regions in the brain are characterized by unique functional profiles and sharp boundaries, consistent with the systems neuroscience definition of true "cortical areas."

Identifiers

PMID42523217
PMCPMC13404652

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.