Evidence map›Paper›PMID 42523213›Full record

ArticlebioRxiv : the preprint server for biology2026

Phosphocitrate Is Superior to Pyrophosphate in Preventing Soft Connective Tissue Calcification in a Mouse Model of Pseudoxanthoma Elasticum.

Ibtesam Rajpar, Christina Shao, Celina Ng, Fatemeh Niaziorimi, Jacob Beiriger, Petri Turhanen, Koen van de Wetering

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ibtesam RajparDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Christina ShaoDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Celina NgDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Fatemeh NiaziorimiDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Jacob BeirigerDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Petri TurhanenSchool of Pharmacy, University of Eastern Finland, Biocenter Kuopio, Kuopio, Finland.
Koen van de WeteringDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

Funding

The role of endogenous low molecular weight mineralization inhibitors in spine healthR01AR082460 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI Makarand V Risbud, Koen van de Wetering · 2024 to 2026
$1.9M
Characterization of ENTPD1 as a drug target in PXER21AR083597 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI VAN DE WETERING, KOEN · 2023 to 2023
$378k
NIAMS NIH HHS R01 AR082460NIAMS NIH HHS R21 AR083597
6 · The paper itself

Abstract

Pseudoxanthoma elasticum (PXE) is a rare inherited disorder characterized by progressive ectopic calcification of soft connective tissues, including skin, arteries, and eyes, leading to significant morbidity. PXE results from loss of functional ABCC6, a liver specific ATP efflux conduit. Reduced ATP release into the circulation limits its conversion into AMP and the mineralization inhibitor pyrophosphate (PPi). Consequently, low plasma PPi levels drive ectopic calcification in PXE. Although oral PPi supplementation can inhibit ectopic calcification in Abcc6

Identifiers

PMID42523213
PMCPMC13404673

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.