In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Sridevi VenkatesanTerrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-9175-7161 Patricia NanoDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5507-2656 Jonathan WernerTerrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Sonia MalaiyaGraduate Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD USA.ORCID 0000-0002-0010-3259 Brian HerbInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD USA.ORCID 0000-0002-5910-9647 Yuan GaoAllen Institute for Brain Science, Seattle, WA, USA.
Li WangDepartment of Biology, Stanford University, CA, USA.
Aparna BhaduriDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4625-6899 Tomasz J NowakowskiDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2345-4964 Carlo ColantuoniInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD USA.ORCID 0000-0001-6818-6380 Seth A AmentInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD USA.ORCID 0000-0001-6443-7509 Jesse GillisTerrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-0936-9774 Funding
Comprehensive single-cell atlas of the developing mouse brainU01MH130962 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta, Tomasz Nowakowski · 2022 to 2026
$33.3MA Multidisciplinary Center for Developing Human and Non-human Primate Brain Cell AtlasesUM1MH130991 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Hao Huang, ARNOLD KRIEGSTEIN · 2022 to 2026
$25.2MA BRAIN Initiative Resource: The Neuroscience Multi-omic Data ArchiveR24MH114788 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI Anup Mahurkar, Owen R White · 2017 to 2026
$17.2MNeuroinflammation, Epigenetics and Male VulnerabilityR01MH052716 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI MARGARET M. MCCARTHY · 2000 to 2026
$9.6MScalable Molecular Pipelines for FAIR and Reusable BICAN Molecular DataU24MH130968 · NIMH · BROAD INSTITUTE, INC. · PI TIMOTHY L TICKLE, Owen R White · 2022 to 2026
$8.3MAssessing Genomic, Regulatory and Transcriptional Variation at Single Nuclei Resolution in the Brains of Individuals with Autism Spectrum DisorderR01MH125516 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD KRIEGSTEIN, Tomasz Nowakowski · 2021 to 2026
$3.8MElucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment DisordersR01MH132689 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aparna Bhaduri · 2024 to 2026
$2.1MIdentifying mechanisms ofsynapse maturation at neuronal subtype resolutionR00MH131832 · NIMH · STANFORD UNIVERSITY · PI Li Wang · 2026 to 2026
$249kNIMH NIH HHS R00 MH131832NIMH NIH HHS R01 MH052716NIMH NIH HHS R01 MH125516NIMH NIH HHS R01 MH132689NIMH NIH HHS R24 MH114788NIMH NIH HHS U01 MH130962NIMH NIH HHS U24 MH130968NIMH NIH HHS UM1 MH130991
6 · The paper itselfAbstract
Human neurodevelopment is a continuous process that begins prenatally and extends into postnatal life. Current transcriptomic datasets are limited, fragmented across analytical frameworks, precluding comprehensive reconstruction of cellular trajectories linking developmental states to mature cell types. Here we present a consolidated cellular-resolution transcriptomic atlas of human brain development from the onset of neurogenesis to adulthood, covering ~2.2 million cells from 156 donors across nine studies. All data were reprocessed from raw sequencing reads and annotated within a unified cell-type taxonomy, enabling reliable mapping across the lifespan. Cell types were highly replicable across heterogeneous datasets, enabling us to chart their maturation and cortical layer localization over time. We identify dynamic gene programs predictive of cell-type maturation, validate gene modules tracking known fate transitions, and leverage our atlas' scale to characterize rare populations, including microglia. This resource establishes a standardized reference of human brain development and maturation gene modules for future comparisons across model systems, species, and disease states.
Identifiers
PMID42523206
PMCPMC13404730
What OpenQuestion holds
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LicenceCC BY
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