Evidence map›Paper›PMID 42523162›Full record

ArticleThe Journal of international medical research2026

Naringin sensitizes nasopharyngeal carcinoma cells to paclitaxel by inducing

Zhenhe Huang, Yumei Qiu, Fangchu Liu, Xiaoli Chen, Xintao Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhenhe HuangDepartment of Otolaryngology Head and Neck Surgery, Ganzhou People's Hospital, China.
Yumei QiuGanzhou Key Laboratory of Molecular Medicine, Ganzhou People's Hospital, China.ORCID 0009-0000-3116-7792
Fangchu LiuDepartment of Otolaryngology Head and Neck Surgery, Ganzhou People's Hospital, China.
Xiaoli ChenGanzhou Key Laboratory of Molecular Medicine, Ganzhou People's Hospital, China.
Xintao WangDepartment of Otolaryngology Head and Neck Surgery, Ganzhou People's Hospital, China.ORCID 0009-0001-4337-1974

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo investigate whether naringin enhances the chemosensitivity of nasopharyngeal carcinoma-derived CNE2 cells to paclitaxel and identify potential molecular mediators.MethodsCNE2 cells were treated with naringin alone or in combination with paclitaxel, cisplatin, or 5-fluorouracil. Cell viability, proliferation, and migration were assessed using cell counting kit-8 and Transwell assays. Transcriptomic profiling followed by bioinformatic analysis of Gene Expression Omnibus datasets (GSE53819, GSE12452, and GSE102349) was performed to identify nasopharyngeal carcinoma prognosis-related genes.

Indexed as

Aldo-Keto Reductase Family 1 Member C3FlavanonesNasopharyngeal CarcinomaNasopharyngeal NeoplasmsPaclitaxelCell Line, TumorCell MovementCell ProliferationCell SurvivalCisplatinDrug Resistance, NeoplasmDrug SynergismFluorouracilGene Expression Regulation, NeoplasticHumansAKR1C3 protein, humanAldo-Keto Reductase Family 1 Member C3CisplatinFlavanonesFluorouracilnaringinPaclitaxelAKR1C3chemosensitizationnaringinNasopharyngeal carcinomapaclitaxel

Identifiers

PMID42523162
PMCPMC13424529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.