Evidence map›Paper›PMID 42523117›Full record

ArticleJournal of virology2026

AAV2 bypasses direct endosomal escape by using AAVR to access the trans-Golgi network en route to the nucleus.

Marti Cabanes-Creus, Sophia H Y Liao, Marta Pardo-Piñón, Adriana L Rojas, Joseph Kelich, Jackson Coyne, Maddison Knight, Deborah Nazareth, Ramon Roca-Pinilla, Sujata Senapati and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marti Cabanes-CreusTranslational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-5412-5701
Sophia H Y LiaoTranslational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Marta Pardo-PiñónBiofisika Institute (CSIC-UPV/EHU), University of the Basque Country, Leioa, Spain.
Adriana L RojasElectron Microscopy and Crystallography Platforms, CIC bioGUNE, Derio, Spain.ORCID 0000-0002-7358-3505
Joseph KelichSpark Therapeutics, Philadelphia, Pennsylvania, USA.
Jackson CoyneSpark Therapeutics, Philadelphia, Pennsylvania, USA.
Maddison KnightTranslational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Deborah NazarethTranslational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Ramon Roca-PinillaTranslational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Sujata SenapatiSpark Therapeutics, Philadelphia, Pennsylvania, USA.
Matthew C WalshSpark Therapeutics, Philadelphia, Pennsylvania, USA.
Pedro J CejasSpark Therapeutics, Philadelphia, Pennsylvania, USA.
Sean M ArmourSpark Therapeutics, Philadelphia, Pennsylvania, USA.
Aitor HierroBiofisika Institute (CSIC-UPV/EHU), University of the Basque Country, Leioa, Spain.
Leszek LisowskiTranslational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-4772-8651

Funding

Spanish State Research Agency PID2023-151986NB-I00
6 · The paper itself

Abstract

Vectors based on the adeno-associated virus are widely used as delivery methods in gene therapy applications, yet understanding of the mechanisms governing its intracellular trafficking remains incomplete. Traditional models suggest that AAV escapes from endosomes via membrane disruption, but direct evidence for this process is lacking. Here, we show that AAVR, the essential AAV cell entry receptor, functions as a bona fide retromer cargo. Using

Indexed as

Cell NucleusDependovirusEndosomesReceptors, Virustrans-Golgi NetworkCapsidGenetic VectorsHumansProtein TransportReceptors, Cell SurfaceTransduction, GeneticKIAA0319L protein, humanReceptors, Cell SurfaceReceptors, VirusAAVAAV-REndosomal traffickingvectorology

Identifiers

PMID42523117
PMCPMC13483459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.