Evidence map›Paper›PMID 42523113›Full record

ArticleMicrobiology spectrum2026

Genome-wide identification of conditionally essential genes for growth in the presence of sulfamethoxazole and trimethoprim in sulfamethoxazole- and trimethoprim-resistant

Sajid Nisar, Mosaed S Alobaidallah, Sandra M Wellner, Nader Abdelmalek, Mauro M Saraiva, Line E Thomsen, John E Olsen

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sajid NisarDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Mosaed S AlobaidallahDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Sandra M WellnerDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Nader AbdelmalekUnit of Microbiology and Virology, Department of Biomedical Sciences, University Hospital of Sassari, University of Sassari, Sassari, Italy.
Mauro M SaraivaDepartment of Pathology, Reproduction, and One Health, Universidade Estadual Paulista-Unesp-FCAV, Jaboticabal, Brazil.
Line E ThomsenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0001-5460-9178
John E OlsenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0001-6225-6587

Funding

Punjab Educational Endowment Fund PEEF/CMMS/20/104
6 · The paper itself

Abstract

Resistance to sulfonamides (SULs) and trimethoprim (TMP) in IMPORTANCE: Sulfonamides (SULs) and trimethoprim (TMP) are broad-spectrum antimicrobials. They are commonly used to treat infections in both humans and animals. Resistance against SUL and TMP is widespread in pathogenic bacteria, and there is a need to overcome this problem. One possibility is to target the cellular mechanism by which the resistant bacteria adapt to growth in the presence of the antimicrobials. In this study, we identify the genes, besides the resistance genes, which enable resistant

Indexed as

Anti-Bacterial AgentsEscherichia coliGenes, EssentialSulfamethoxazoleTrimethoprimDrug Resistance, Multiple, BacterialEscherichia coli ProteinsGenome, BacterialMicrobial Sensitivity TestsAnti-Bacterial AgentsEscherichia coli ProteinsSulfamethoxazoleTrimethoprimantibiotic resistanceconditionally essential genessulfonamidesTMPTraDIS

Identifiers

PMID42523113
PMCPMC13532273

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.