Evidence map›Paper›PMID 42523078›Full record

ArticleBiomaterials science2026

Investigating the coupled effects of stiffness and stretch on the trabecular meshwork cells using a hydrogel-integrated microfluidic system.

Kanghoon Choi, Minju Kim, Monika Lakk, Fiona S McDonnell, David Krizaj, Jungkyu Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kanghoon ChoiDepartment of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA. jkim@mech.utah.edu.ORCID http://orcid.org/0009-0006-6227-632X
Minju KimDepartment of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA. jkim@mech.utah.edu.ORCID http://orcid.org/0009-0006-9332-0573
Monika LakkDepartment of Ophthalmology & Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Fiona S McDonnellDepartment of Ophthalmology & Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
David KrizajDepartment of Ophthalmology & Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Jungkyu KimDepartment of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA. jkim@mech.utah.edu.ORCID http://orcid.org/0000-0003-3691-6953

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jun Yang · 2005 to 2026
$14.6M
Replacement of the Flexcell Tension systemR01EY027920 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ · 2017 to 2026
$3.5M
Vision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3M
Cellular and Molecular Mechanisms that Contribute to Pressure-Induced Retinal Inflammation and PathologyR01EY031817 · NEI · UNIVERSITY OF UTAH · PI KRIZAJ, DAVID · 2021 to 2024
$1.5M
NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY027920NEI NIH HHS R01 EY031817NEI NIH HHS T32 EY024234
6 · The paper itself

Abstract

Glaucoma is characterized by progressive stiffening of the trabecular meshwork (TM), which is associated with elevated intraocular pressure and tissue dysfunction. Although substrate stiffness and mechanical stretch both regulate TM homeostasis, their combined effects remain poorly understood. Here, a hydrogel-integrated microfluidic platform is presented that enables simultaneous control of substrate stiffness,

Indexed as

HydrogelsMicrofluidicsTrabecular MeshworkActinsAnimalsCells, CulturedCollagen Type ICytoskeletal ProteinsEye ProteinsGlaucomaGlycoproteinsHumansMatrix Metalloproteinase 2MyocilinStress, MechanicalActinsCollagen Type ICytoskeletal ProteinsEye ProteinsGlycoproteinsHydrogelsMatrix Metalloproteinase 2Myocilin

Identifiers

PMID42523078
PMCPMC13509035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.