ArticleTheScientificWorldJournal2026
Glomerular Crescents in Adult Lupus Nephritis: Clinical and Pathological Insights From Saudi Arabia.
Article in TheScientificWorldJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Glomerular Crescents in Adult Lupus Nephritis: Clinical and Pathological Insights From Saudi Arabia.TheScientificWorldJournal · 2026Article
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11 authors.
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Abstract
backgroundCrescent formation is a marker of severe kidney injury in lupus nephritis (LN), but data from Saudi Arabia are scarce. We studied how crescents affect clinical features, pathology, and outcomes in Saudi patients.
methodsWe reviewed 100 adults with biopsy-proven LN (2003-2024), classifying them by the presence and type of crescents (cellular, fibrocellular, fibrous). Crescent burden was calculated as the percentage of glomeruli involved; ≥ 7.39% was considered high. The composite renal outcome included estimated glomerular filtration rate (eGFR) < 20 mL/min/1.73 m
resultsOut of 100 patients with LN, 41 (41%) had crescents. Those with crescents had lower eGFR (71.41 ± 43.92 vs. 100.12 ± 45.63 mL/min/1.73 m
conclusionCrescents indicate more active disease and worse kidney function at diagnosis. While a high crescent burden may signal poorer short-term outcomes, long-term prognosis depends more on other clinical and pathological factors. Assessing both clinical presentation and biopsy findings is important for managing LN.
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