Evidence map›Paper›PMID 42522591›Full record

ArticleContact dermatitis2026

Occupational Contact Allergy to Components of Epoxy Resin Systems: Descriptive and Comparative Epidemiological Analyses Based on IVDK Data 2008-2022.

David Reissig, Katharina Heymann, Steffen Schubert, Richard Brans, Birger Kränke, Eva Oppel, Rüdiger Panzer, Dagmar Simon, Andrea Bauer, IVDK

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Contact dermatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David ReissigDepartment of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0002-6192-1538
Katharina HeymannDepartment of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Steffen SchubertInformation Network of Departments of Dermatology (IVDK), Institute at the Georg-August University Göttingen, University Medical Centre Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0002-2359-2518
Richard BransInstitute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm), Osnabrück University, Osnabrück, Germany.ORCID https://orcid.org/0000-0002-1245-024X
Birger KränkeDepartment of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
Eva OppelDepartment of Dermatology and Allergology, Ludwig-Maximilians-University, Munich, Germany.ORCID https://orcid.org/0000-0002-8412-2667
Rüdiger PanzerClinic and Policlinic for Dermatology, Venereology, and Allergology, University Medical Center Rostock, Rostock, Germany.ORCID https://orcid.org/0009-0009-2734-7534
Dagmar SimonDepartment of Dermatology, Bern University Hospital, Bern, Switzerland.ORCID https://orcid.org/0000-0001-8965-9407
Andrea BauerDepartment of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0002-4411-3088
IVDK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpoxy resin systems (ERS) frequently cause occupational allergic contact dermatitis.

objectivesTo analyze and update sensitization frequencies to epoxy resin, reactive diluents and hardeners in patients with occupational dermatitis (OD).

methodsRetrospective descriptive and comparative analysis of data collected by the Information Network of Departments of Dermatology (IVDK) from OD patients patch tested with bisphenol A diglycidyl ether (DGEBA) epoxy resin, 2008-2022.

resultsDGEBA sensitization declined overall, with fluctuations, from 4.2% in 2008-2010 to 2.9% in 2020-2022 (p = 0.0014). Adjusted odds ratios (ORs) were highest for plastics processors (11.7; 95% CI, 8.1-16.6), bricklayers, cement and concrete workers (6.4; 5.1-8.0), and painters/varnishers (5.3; 4.0-6.9). DGEBA-positive patients were most frequently co-sensitised to the reactive diluents 1,6-hexanediol diglycidyl ether (43.6%), 1,4-butanediol diglycidyl ether (35.7%), and phenyl glycidyl ether (30.8%), and to the hardener m-xylylenediamine (22.7%). DGEBA testing alone would not have identified 446 patients (1.9% of all DGEBA-tested OD patients) with sensitizations to reactive diluents or amine hardeners.

conclusionsIf contact allergy to ERS components is suspected, not only DGEBA, but also reactive diluents and hardeners should be patch tested. Prevention should prioritise exposure control, occupational hygiene, ongoing surveillance, and periodic test series updates.

Indexed as

Dermatitis, Allergic ContactDermatitis, OccupationalEpoxy CompoundsEpoxy ResinsAdultBenzhydryl CompoundsBisphenol A CompoundsBisphenolsFemaleHumansMalePatch TestsRetrospective StudiesBenzhydryl CompoundsBisphenol A Compoundsbisphenol A diglycidyl etherBisphenolsEpoxy CompoundsEpoxy Resins

Identifiers

PMID42522591
PMCPMC13648310

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.