Evidence map›Paper›PMID 42522467›Full record

ArticlePathology international2026

Marked Anaplasia Obscuring the Diagnosis of Clear Cell Sarcoma of the Kidney in Pretreatment Needle Biopsy.

Masahiro Fukuhara, Kenichi Kohashi, Amane Kamouchi, Takumi Tomonaga, Yoshiki Yamaguchi, Kenta Ishimoto, Yuko Hino, Junnosuke Maniwa, Naonori Kawakubo, Shunsuke Yamamoto and 5 more

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In one paragraph

Article in Pathology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Masahiro FukuharaDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.ORCID https://orcid.org/0000-0002-4162-9361
Kenichi KohashiDepartment of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.ORCID https://orcid.org/0000-0002-2358-7452
Amane KamouchiDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Takumi TomonagaDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Yoshiki YamaguchiDepartment of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Kenta IshimotoDepartment of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Yuko HinoDepartment of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Junnosuke ManiwaDepartment of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Naonori KawakuboDepartment of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.ORCID https://orcid.org/0000-0003-0010-4902
Shunsuke YamamotoDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Utako ObaDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Kentaro NakashimaDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Yasunari SakaiDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Tatsuro TajiriDepartment of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.ORCID https://orcid.org/0009-0006-6314-2024
Yoshinao OdaDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.ORCID https://orcid.org/0000-0001-9636-1182

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear cell sarcoma of the kidney is an uncommon pediatric renal malignancy with metastatic potential and marked morphologic heterogeneity. The anaplastic variant is rare and may mimic other high-grade pediatric renal tumors, resulting in diagnostic challenges in limited pretreatment biopsy specimens. A 3-year-old girl presented with progressive abdominal distension. Imaging showed a 15-cm right retroperitoneal mass with tumor thrombus in the inferior vena cava and no distant metastasis. Pretreatment core needle biopsy showed a highly pleomorphic malignant neoplasm with necrosis and fibrous-to-myxoid stroma; however, a definitive diagnosis could not be established. The patient was clinically managed as a nephroblastoma and received preoperative chemotherapy followed by surgical resection. The resected specimen showed features characteristic of clear cell sarcoma of the kidney. Immunoreactivity of BCL6 corepressor and cyclin D1 was observed, whereas Wilms tumor 1 was negative. Molecular testing further identified an in-frame internal tandem duplication of BCOR. Retrospective immunohistochemistry on the pretreatment biopsy demonstrated concordant BCOR and cyclin D1 expression. Marked anaplasia can obscure the typical morphology of clear cell sarcoma of the kidney. Immunohistochemistry for BCL6 corepressor and cyclin D1 at an early diagnostic stage, with molecular confirmation may facilitate accurate diagnosis and timely treatment.

Indexed as

Kidney NeoplasmsSarcoma, Clear CellAnaplasiaBiomarkers, TumorBiopsy, NeedleChild, PreschoolCyclin D1FemaleHumansImmunohistochemistryProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-6Repressor ProteinsBCL6 protein, humanBCOR protein, humanBiomarkers, TumorCCND1 protein, humanCyclin D1Proto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-6Repressor Proteinsanaplasiabiopsyclear cellimmunohistochemistrykidney neoplasmneedlesarcoma

Identifiers

PMID42522467
PMCPMC13416797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.