ArticleActa obstetricia et gynecologica Scandinavica2026
Angiogenic biomarker concentrations and their relation to coronary atherosclerosis in women with a history of preeclampsia: Findings from the CPH-PRECIOUS study.
Article in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPreeclampsia is known to be associated with a two- to fourfold elevated risk of developing cardiovascular disease in the first 15 years following pregnancy. In this cross-sectional study of 892 women with prior preeclampsia, we aimed to assess differences in circulating angiogenic biomarker concentrations according to CT-assessed coronary atherosclerosis in women up to 28 years after an index pregnancy complicated by preeclampsia. MATERIAL AND
methodsWomen were identified from clinical databases consisting of data from all deliveries within the Capital Region of Denmark from 1995 onwards. Women with prior preeclampsia and a current age between 35 and 55 years were included from the CPH-PRECIOUS cohort. The primary outcome was differences in circulating angiogenic biomarkers according to CT-assessed coronary atherosclerosis.
resultsThe median time since the pregnancy complicated by preeclampsia was 12.5 years (range: 0-28 years). PlGF concentrations were significantly higher in women with coronary atherosclerosis (9.6 pg/mL [IQR 4.9-12.6] vs. 7.4 pg/mL [IQR 3.9-11.3], p = 0.001), and subsequently a lower calculated sFlt-1/PlGF ratio (4.2 [IQR 3.1-6.3] vs. 5.0 [IQR 3.6-6.9], p = 0.001) was found. No differences in sFlt-1 concentrations were observed. Higher PlGF concentrations were significantly associated with coronary atherosclerosis; however, associations were attenuated in adjusted analysis.
conclusionsThis is the first large study to investigate long-term differences in circulating angiogenic biomarker concentrations after preeclampsia, highlighting the complex relationship between angiogenic biomarkers, preeclampsia, and later atherosclerotic burden.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.