Evidence map›Paper›PMID 42522366›Full record

ArticleJournal of periodontology2026

Roles of CCL2 in peri-implantitis and its potential as a treatment target: An animal study.

Anqi Zhou, Yiping Wei, Wenting Jiang, Shasha Yuan, Ting Yang, Yaqian Mo, Xuekang Wang, Qingqing Li, Zhanming Song, Zhongtian Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anqi ZhouDepartment of Periodontology, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.ORCID https://orcid.org/0000-0002-2696-7231
Yiping WeiDepartment of Periodontology, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.ORCID https://orcid.org/0000-0002-8517-3757
Wenting JiangFujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0002-2491-5569
Shasha YuanDepartment of Periodontology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.
Ting YangDepartment of Periodontology, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.ORCID https://orcid.org/0009-0004-6614-4522
Yaqian MoDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Xuekang WangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Qingqing LiDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Zhanming SongDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Zhongtian LiuDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Ning LiDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Zhaohuai ZhangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Ying WangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.ORCID https://orcid.org/0000-0001-5224-6692
Wenjie HuDepartment of Periodontology, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.ORCID https://orcid.org/0000-0002-8772-2705

Funding

National Natural Science Foundation of China 82173647National Natural Science Foundation of China 82271884Natural Science Foundation of Beijing Municipality 7232089Research Foundation of Peking University School and Hospital of Stomatology PKUSS20240102
6 · The paper itself

Abstract

backgroundCC-chemokine ligand 2 (CCL2) plays pivotal roles in many osteoimmune disorders, while its role in peri-implantitis is unknown. The main research question aimed to address in this study is investigating the specific roles of CCL2 in peri-implantitis and assessing the preventive and therapeutic effects of bindarit on experimental peri-implantitis.

methodsFirstly, the expression profile of CC-chemokine receptor 2 ligands in human peri-implantitis was ascertained by processing and analyzing datasets from the Gene Expression Omnibus database. Then the experimental peri-implantitis model was established in mice by suture ligation, and the soft tissue inflammation and hard tissue resorption were compared in CCL2 knockout (Ccl2

resultsCCL2 demonstrated a significant predominant expression among the ligands of CC-chemokine receptor 2 in human peri-implantitis. CCL2 was significantly upregulated in the ligature-induced peri-implantitis model (p = 0.0007), and CCL2 deficiency resulted in significantly decreased monocytes/macrophages infiltration in peri-implant tissue (CD45

conclusionsThe findings of this study suggest that CCL2 may serve as a potential target for peri-implantitis treatment by mediating peri-implant host immune response to modulate local inflammation and bone resorption, offering a new direction for the development of immunotherapeutic drugs for this condition. PLAIN LANGUAGE SUMMARY: Peri-implantitis, an inflammatory condition that impacts the longevity of dental implants, poses considerable challenges due to the limited effectiveness of current treatment methods. This study aimed to understand the role of CC-chemokine ligand 2 (CCL2) in this condition. In our study, CCL2 was discovered to be the primary ligand of CC-chemokine receptor 2 in peri-implantitis. Lab tests using a mouse model revealed that in the absence of CCL2, inflammation and bone loss were reduced. Furthermore, this study confirmed the effect of a drug called bindarit, which inhibits CCL2, in treating experimental peri-implantitis. Investigating the specific roles of CCL2 and assessing the potential benefits of bindarit in managing peri-implantitis provide a scientific foundation for exploring new treatment strategies.

Indexed as

Chemokine CCL2Peri-ImplantitisAnimalsDisease Models, AnimalHumansIndazolesMaleMiceMice, Inbred C57BLMice, KnockoutPropionatesbindaritCcl2 protein, mouseChemokine CCL2IndazolesPropionatesbindaritCCL2chemokinemonocytes/macrophagesperi‐implantitis

Identifiers

PMID42522366
PMCPMC13568988

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.