ReviewStem cells translational medicine2026
From elective protocols to emergency reality: rethinking adipose tissue harvesting for stromal vascular fraction applications.
Review in Stem cells translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipose tissue is a readily accessible source of stromal vascular fraction (SVF) and adipose-derived stem/stromal cells, widely used in regenerative medicine. Current harvesting and processing standards are derived almost exclusively from elective surgical settings performed under controlled physiological conditions. However, expanding applications in trauma and neurosurgery increasingly require adipose tissue procurement in emergency settings, where systemic inflammation, hypoperfusion, and time constraints may alter tissue biology. The biological impact of emergency harvesting remains insufficiently characterized, yet this knowledge is critical for optimizing SVF-based regenerative medicine strategies in emergency surgical environments.
objectivesTo evaluate how emergency adipose procurement may influence SVF quality, cellular yield, viability, and translational feasibility, and to propose an acute-care-adapted framework for clinical integration.
methodsA comprehensive search of PubMed, EMBASE, and Scopus (inception-January 2026) identified studies addressing harvesting techniques, donor-site variability, enzymatic vs mechanical isolation, time-to-processing effects, cryopreservation, contamination risk, and clinical outcomes. Data were synthesized narratively with emphasis on variables relevant to emergency settings.
resultsHarvesting parameters-including cannula diameter and negative pressure-influence total nucleated cell yield and viability. Enzymatic digestion increases cell recovery by approximately 1.5- to 3-fold compared with mechanical fractionation but requires laboratory infrastructure and a longer processing time. Mechanical techniques enable rapid point-of-care application yet produce stromal vascular tissue with greater heterogeneity. Processing delays reduce viable cell counts. Emergency physiology introduces additional upstream modifiers, including cytokine activation and microvascular perturbation, that remain largely unstudied in SVF research.
conclusionsEmergency adipose harvesting challenges elective-based assumptions underlying current SVF standards. Context-specific comparative studies and standardized emergency-adapted protocols are required to ensure biological robustness and clinical safety in acute surgical environments.
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Registered trials
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