Evidence map›Paper›PMID 42522173›Full record

Trial reportPain research & management2026

Combining Pulsed Radiofrequency With Transcranial Magnetic Stimulation to Manage Hemiplegic Shoulder Pain and Somatosensory Nerve Transmissions.

Ying Zhao, Xuehan Zang, Lingyan Wang, Zhengmei Yan, Jun Yang, Qingchuan Gu, Li Zhou, Xianwei Che, Aiqun Shi, Jiasheng Wang

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying ZhaoDepartment of Rehabilitation Medicine, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jinhua, China.ORCID https://orcid.org/0000-0001-9028-2352
Xuehan ZangCentre for Cognition and Brain Disorders, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.ORCID https://orcid.org/0009-0003-8364-2796
Lingyan WangDepartment of Rehabilitation Medicine, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jinhua, China.ORCID https://orcid.org/0000-0003-4113-936X
Zhengmei YanDepartment of Rehabilitation Medicine, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jinhua, China.ORCID https://orcid.org/0009-0000-7823-3734
Jun YangDepartment of Rehabilitation Medicine, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jinhua, China.ORCID https://orcid.org/0009-0003-9041-9648
Qingchuan GuDepartment of Rehabilitation Medicine, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jinhua, China.ORCID https://orcid.org/0009-0007-1908-5656
Li ZhouDepartment of Pain Medicine, Ningbo No. 6 Hospital, Ningbo, China, nbdlyy.com.ORCID https://orcid.org/0009-0008-0558-5585
Xianwei CheCentre for Cognition and Brain Disorders, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.ORCID https://orcid.org/0000-0002-0039-7306
Aiqun ShiDepartment of Rehabilitation Medicine, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jinhua, China.ORCID https://orcid.org/0000-0002-1296-4806
Jiasheng WangDepartment of Rehabilitation Medicine, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jinhua, China.ORCID https://orcid.org/0009-0006-5872-5698

Funding

Jinhua Science and Technology Bureau 2023-3-142
6 · The paper itself

Abstract

backgroundHemiplegic shoulder pain (HSP) is a major cause of disability that is still challenging to manage in clinical practices. Both pulsed radiofrequency (PRF) and repetitive transcranial magnetic stimulation (rTMS) could reduce poststroke HSP to certain extents. However, it remains unknown whether combined PRF and rTMS treatment could increase analgesic efficacy for poststroke HSP.

objectivesTo evaluate the therapeutic efficacy of combined PRF and transcranial magnetic stimulation in treating HSP. STUDY

designThis was a randomized, assessor-blinded pilot study.

settingThe rehabilitation department of a single hospital.

methodsIn this pilot study, a 3-arm study design was utilized to compare the treatment efficacy of combined PRF and rTMS treatment with a single PRF or rTMS strategy. Patients were randomly assigned to receive PRF, rTMS, or combined treatment. Outcomes assessments included pain intensity, motor activity, and neurophysiological activities.

resultsOur data indicated that rTMS acted more efficiently to reduce pain than PRF treatment. Combined treatment had a larger long-term efficacy than rTMS treatment alone. Both combined and single treatment improved motor recovery and neural transmissions, such as suprascapular nerve amplitude and somatosensory N20. LIMITATIONS: As we designed a pilot study, the sample size was small in each treatment arm. Our findings thus need to be validated in future large studies. CONCLUSION(S): These novel findings provide a safe and effective treatment strategy for poststroke HSP by combining PRF with rTMS treatment.

trial registrationChinese Clinical Trial Registry: ChiCTR2500100181.

Indexed as

HemiplegiaPulsed Radiofrequency TreatmentShoulder PainTranscranial Magnetic StimulationAdultAgedCombined Modality TherapyFemaleHumansMaleMiddle AgedPain MeasurementPilot ProjectsSingle-Blind MethodStrokeTreatment Outcomehemiplegic shoulder painpainpulsed radiofrequencyrepetitive transcranial magnetic stimulationstroke

Identifiers

PMID42522173
PMCPMC13415992

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.