ArticleAdvanced healthcare materials2026
Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic-Immunomodulatory Prevention of CIED Infection in Diabetes.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang and 4 more
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In one paragraphArticle in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
Honghao MaDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Rongrong GuAgricultural Photocatalysis Laboratory, School of Materials and Chemistry, Anhui Agricultural University, Hefei, China.
Chuanhui DongAgricultural Photocatalysis Laboratory, School of Materials and Chemistry, Anhui Agricultural University, Hefei, China.
Te ChenDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yi MuDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Jing ZhuAgricultural Photocatalysis Laboratory, School of Materials and Chemistry, Anhui Agricultural University, Hefei, China.
Yating WangDepartment of Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Wen WangDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yingying ZhangDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hongyu MaThe Key Laboratory of Urinary Tract Tumors and Calculi, Department of Urology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.ORCID https://orcid.org/0009-0002-8324-8433 Xiaochen WangDepartment of Cardiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Funding
2025 Health Science and Technology Project of the Health Commission of Anhui Province 2025Ab30081Anhui Natural Science Foundation for Outstanding Young Scholars 2408085Y008Basic and Clinical Enhancement Project of Anhui Medical University 2020xkjT036Clinical and Translational Research Project of Anhui Province 202427b10020131National Natural Science Foundation of China 22372001National Natural Science Foundation of China 82102308Provincial quality project of University in Anhui province 2024xsxx136research and application of precise left atrial appendage occlusion under full three-dimensional and radiation-free guidance of Anhui Medical University 202427610020062Starting Fund for the Doctoral Research at Anhui Normal University 762634
6 · The paper itselfAbstract
Diabetic patients face heightened risks for cardiac implantable electronic devices (CIED) infections. Herein, we developed a near-infrared (NIR)-activated porphyrin polymer (PTCPP) for photodynamic therapy of CIED infections, which achieves a 100% antibacterial rate with a 22% increase in anti-biofilm efficacy compared to porphyrin (TCPP) in vitro. In diabetic rats, a 93% bactericidal rate is further demonstrated by PTCPP, along with a 97% reduction in the levels of pro-inflammatory factors. It is found that singlet oxygen (
Indexed as
Diabetes Mellitus, ExperimentalPhotochemotherapyPolymersPorphyrinsAnimalsAnti-Bacterial AgentsBiofilmsMethicillin-Resistant Staphylococcus aureusPhotosensitizing AgentsRatsRats, Sprague-DawleyReactive Oxygen SpeciesStaphylococcal InfectionsAnti-Bacterial AgentsPhotosensitizing AgentsPolymersPorphyrinsReactive Oxygen Speciesantimicrobial filmimmune regulationphotodynamicwound healing
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