ArticleIET systems biology
Exposure the Hazardous Potential of Quinalphos: An In-Depth Analysis for Environmental and Biological Effects on Human Health.
Article in IET systems biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quinalphos pesticide (QP) exposure can lead to various human health effects, including anaemia, leucocytosis with neutrophilia, hepatic damage and oxidative stress. Acute poisoning symptoms include weakness, sweating, impaired vision and neurological distress. Additionally, neurological and reproductive abnormalities have been reported in specific exposure scenarios. This study identified 16 differentially expressed genes from clinical exposure research. Integrating omics data using network biology approaches has shown that QP significantly alters the expression of 16 genes predicted to be regulated by 26 transcription factors and 41 miRNAs. The molecular docking predicted AR, ESR1, NR1I2, ESR2, CYP19A1 and JUN to have the highest binding affinity with QP. Gene ontology analysis of the DEGs revealed enrichment in pathways related to genital development, oestrogen receptor signalling, prostate gland development and response to vitamin A. The three most influential pathways by these DEGs are detected with significant enrichment in diseases, and they are linked to Cytochrome P450, arranged by substrate type, nuclear receptor transcription pathway and SUMOylation of intracellular receptors. The analysis identified 1445 drugs for 15 genes for potential drug repurposing. The network was pruned by applying the threshold value 0.1 STITCH database and score value 0.1 of the DGIdb database, resulting in the identification of 446 drug (approved and non-approved) therapeutic targets. This analysis provides a comprehensive understanding of the mechanisms of QP-induced toxicity, focusing on humans, and underscores the need for further studies on exposure to QP, providing valuable insights for toxicological risk assessment and regulatory evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.