Evidence map›Paper›PMID 42521863›Full record

ArticleArchives of gynecology and obstetrics2026

Evolving paradigms in lymph node surgery in endometrial cancer: insights from the multicenter E-PEC trial.

B Eser, D Papior, J Salmanton-García, O A Cornely, B Morgenstern, C Herpel, J C Radosa, A Almuheimid, B Aktas, L Weydandt and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

B EserDepartment of Gynecology and Obstetrics, University Hospital of Essen, Medical Faculty of the University of Duisburg-Essen, Essen, Germany. buesra.eser@uk-essen.de.
D PapiorDepartment of Gynecology and Obstetrics, University Hospital of Essen, Medical Faculty of the University of Duisburg-Essen, Essen, Germany.
J Salmanton-GarcíaInstitute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
O A CornelyInstitute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
B MorgensternUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Gynecology and Gynecologic Oncology;, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), Bonn, CologneCologne, Düsseldorf, Germany.
C HerpelUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Gynecology and Gynecologic Oncology;, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), Bonn, CologneCologne, Düsseldorf, Germany.
J C RadosaDepartment of Gynecology and Obstetrics, University Hospital of Homburg, Homburg, Germany.
A AlmuheimidDepartment of Gynecology and Obstetrics, University Hospital of Homburg, Homburg, Germany.
B AktasDepartment of Gynecology, University Hospital of Leipzig, Leipzig, Germany.
L WeydandtDepartment of Gynecology, University Hospital of Leipzig, Leipzig, Germany.
J WittenbornDepartment of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany.
P Meyer-WilmesDepartment of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany.
V FriebeDepartment of Gynecology and Obstetrics, University Hospital of Düsseldorf, Düsseldorf, Germany.
C LeidingerDepartment of Gynecology and Obstetrics, University Hospital of Düsseldorf, Düsseldorf, Germany.
P BuderathDepartment of Gynecology and Obstetrics, University Hospital of Essen, Medical Faculty of the University of Duisburg-Essen, Essen, Germany.
R KimmigDepartment of Gynecology and Obstetrics, University Hospital of Essen, Medical Faculty of the University of Duisburg-Essen, Essen, Germany.
F ThangarajahDepartment of Gynecology and Obstetrics, University Hospital of Essen, Medical Faculty of the University of Duisburg-Essen, Essen, Germany. Fabinshy.Thangarajah@uk-essen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe temporal trends in lymph node staging for endometrial cancer in selected German academic centers between 2018 and 2022.

methodsIn this multicenter retrospective cohort study, patients who underwent primary surgical treatment for newly diagnosed endometrial cancer between 2018 and 2022 at six German university hospitals were included. Patients receiving primary systemic or chemoradiation therapy were excluded. Patient characteristics and treatment details were analyzed descriptively and stratified by year of surgery. This multicenter retrospective cohort study was conducted as part of the E-PEC project, an ethics-approved multicenter project assessing surgical management patterns in newly diagnosed endometrial cancer.

resultsA total of 644 patients met the inclusion criteria. Overall, 62.4% underwent lymph node surgery. Sentinel-based procedures were increasingly performed over time and accounted for 61.4% of all nodal staging procedures. In contrast, the rate of primary systematic lymphadenectomy significantly decreased from 30.3% in 2018 to 17.9% in 2022 (p < 0.05).

conclusionsWe observed a temporal increase in less radical lymph node procedures in selected German academic centers during the study period. Sentinel-based techniques were increasingly used over time in parallel with evolving guideline recommendations.

Indexed as

Endometrial NeoplasmsLymph Node ExcisionAgedFemaleGermanyHumansLymphatic MetastasisLymph NodesMiddle AgedNeoplasm StagingRetrospective StudiesSentinel Lymph Node BiopsyEndometrial cancerLymph node assessmentSentinel-node biopsySurgical treatmentSurgical trends

Identifiers

PMID42521863
PMCPMC13415476

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.