Evidence map›Paper›PMID 42521848›Full record

ArticleNature immunology2026

Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens.

Vicente Fajardo-Rosas, Aquib Ehtram, Isabel Marchand-Casas, Serena J Chee, Monalisa Mondal, Celia Ferrández Alaminos, Francisco Emmanuel Castañeda-Castro, Zubin Roy, Lindsey Chudley, Michael Shackcloth and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Vicente Fajardo-Rosas *La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1578-7438
Aquib Ehtram *La Jolla Institute for Immunology, La Jolla, CA, USA.
Isabel Marchand-CasasLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0754-6797
Serena J CheeDepartment of Respiratory Medicine, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.
Monalisa MondalLa Jolla Institute for Immunology, La Jolla, CA, USA.
Celia Ferrández AlaminosLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0009-0003-3027-6147
Francisco Emmanuel Castañeda-CastroLa Jolla Institute for Immunology, La Jolla, CA, USA.
Zubin RoyLa Jolla Institute for Immunology, La Jolla, CA, USA.
Lindsey ChudleyDepartment of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-5202-7104
Michael ShackclothDepartment of Thoracic Surgery, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.ORCID http://orcid.org/0000-0002-6494-9907
Judith CaveDepartment of Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Aiman AlzetaniDepartment of Thoracic Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.ORCID http://orcid.org/0000-0002-3373-6714
Edwin WooDepartment of Thoracic Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Elizabeth PhillipsDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Simon MallalDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7036-1309
Alba GrifoniLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-2209-5966
Benjamin J SchmiedelLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9103-9378
Alessandro SetteLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7013-2250
Bjoern PetersLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8457-6693
Christian H OttensmeierLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3619-1657
Pandurangan VijayanandLa Jolla Institute for Immunology, La Jolla, CA, USA. vijay@lji.org.ORCID http://orcid.org/0000-0001-7067-9723

Funding

Single-cell atlas of lung tissue-resident memory T cells reactive to upper and lower respiratory tract pathogensU19AI118626 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2015 to 2026
$36.7M
NovaSeq5000 High Throughput SequencerS10OD025052 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SEUMOIS, GREGORY · 2018 to 2018
$832k
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
NCRR NIH HHS S10 RR027366NIAID NIH HHS U19 AI118626NIH HHS S10 OD025052NIH HHS S10 OD026929U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI118626
6 · The paper itself

Abstract

Lung tissue-resident memory T (T

Indexed as

CD4-Positive T-LymphocytesLungMemory T CellsReceptors, Antigen, T-CellRespiratory Tract InfectionsAdultAgedAged, 80 and overFemaleHumansImmunologic MemoryMaleMiddle AgedReceptors, Antigen, T-Cell

Identifiers

PMID42521848
PMCPMC13414554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.