ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Inner retinal structure and intraocular pressure in children with obesity.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo test whether pediatric obesity is associated with inner retinal structure and intraocular pressure (IOP) changes, and whether insulin resistance (IR) is associated with additional ophthalmic differences within the obesity subgroup.
methodsThis cross-sectional study enrolled 202 children aged 6-18 years, including 92 with obesity and 110 controls. Both eyes underwent spectral-domain OCT to quantify peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell and inner plexiform layer (GCIPL) thickness; IOP was measured by rebound tonometry. Eye-level generalized estimating equation models accounted for inter-eye correlation and were adjusted for age and sex. Additional sensitivity analyses included axial length and spherical equivalent, and OCT-derived parameters were further assessed after axial length-related magnification correction. Within the obesity group, associations of IR status and selected routine biochemical markers with OCT and IOP parameters were explored.
resultsIn the primary age- and sex-adjusted models, obesity was associated with higher IOP and lower average, temporal, and nasal RNFL thickness. The adjusted IOP difference was 2.48 mmHg. After additional adjustment for axial length and spherical equivalent, the association with higher IOP remained robust, whereas RNFL differences were attenuated; only the temporal RNFL difference remained statistically significant. After magnification correction, RNFL differences no longer reached statistical significance. GCIPL thickness did not differ significantly between groups. Within the obesity subgroup, IR status and selected biochemical markers were not associated with additional OCT or IOP differences.
conclusionIn this cross-sectional pediatric cohort, obesity was associated with higher IOP, and this association remained stable after adjustment for ocular biometry. RNFL differences were sensitive to biometry and magnification correction, whereas GCIPL thickness did not differ significantly. IR was not independently associated with OCT or IOP parameters within the obesity subgroup. Longitudinal studies are needed to determine the clinical relevance of these findings.
Indexed as
Identifiers
42521843What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.