ArticleInternational journal of obesity (2005)2026
The relationship between changes in body weight and cognitive function in the elderly.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive function is a major concern in aging society. Current studies on the impact of body weight changes on cognitive abilities present conflicting results. This study explored the relationship between weight changes during adulthood and cognitive function in later life.
methodsData were obtained from the National Health and Nutrition Examination Survey (NHANES) and a total of 5097 participants aged 60 years or older with recalled weight at young and middle adulthood were included. Absolute weight change was categorized into five groups: weight loss of at least 2.5 kg, weight change within 2.5 kg (reference group), weight gain of at least 2.5 kg but less than 10.0 kg, weight gain of at least 10 kg but less than 20.0 kg, and weight gain of at least 20.0 kg. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST). Logistic regression models adjusted for covariates were used to compute the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between weight changes and cognitive function.
resultsFrom age 25 to 10 years before survey, participants with small to moderate weight gain (increase of ≥2.5 kg and <10 kg) exhibited a decreased risk of cognitive impairment compared to those with stable weight (weight change within 2.5 kg), with an OR of 0.64 (95% CI = 0.48 to 0.85, P = 0.003). For moderate to substantial weight gain (increase of ≥10 kg and <20 kg), the OR was 0.61 (95% CI = 0.46-0.79, P < 0.001). From age 25 years to survey, the OR for moderate to substantial weight gain was 0.66 (95% CI = 0.50-0.89, P = 0.007). Restricted cubic spline indicated a U-shaped relationship between the absolute weight change and cognitive function.
conclusionsModerate weight gain from early adulthood to late life was associated with a reduced risk of cognitive impairment, while weight loss showed a non-significant trend toward increased risk.
Identifiers
42521837What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.