Evidence map›Paper›PMID 42521820›Full record

Trial reportNature medicine2026

Maternal 6-valent group B Streptococcus vaccine in non-pregnant and pregnant females: a randomized phase 1/2 trial.

Shabir A Madhi, Hasra Snaggs, Zahra Skogeby, Ye Feng, Shaun Barnabas, Jeffrey Baker, Lee Fairlie, Johannes Beeslaar, David Radley, Han-Qing Jiang and 8 more

Abstract readClinical Trial, Phase IIRandomized Controlled TrialClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shabir A MadhiSouth African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-7629-0636
Hasra SnaggsPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Zahra SkogebyPfizer Vaccines, Pfizer Ltd, Marlow, UK.
Ye FengPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Shaun BarnabasFamily Center for Research with Ubuntu, Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa.
Jeffrey BakerClinical Research Prime, Idaho Falls, ID, USA.
Lee FairlieWits RHI, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0001-5327-1734
Johannes BeeslaarPfizer Vaccines, Pfizer Ltd, Marlow, UK.
David RadleyPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Han-Qing JiangPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Natalie C Silmon de MonerriPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Raphael SimonPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Lindsay McLaughlinPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Michelle GaylordPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Julie SkinnerPfizer Vaccines, Pfizer Inc., Collegeville, PA, USA.
Iona MunjalPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA. iona.munjal@pfizer.com.ORCID http://orcid.org/0009-0001-8421-828X
Annaliesa S AndersonPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.
Alejandra GurtmanPfizer Vaccines, Pfizer Inc., Pearl River, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group B Streptococcus (GBS) disease is a major cause of infant morbidity and mortality. Capsular polysaccharide conjugate GBS vaccines have been evaluated for decades; however, none is licensed. This phase 1/2 trial evaluated an investigational maternal hexavalent polysaccharide-protein conjugate GBS vaccine (GBS6) in non-pregnant females and pregnant participants and their infants. In stage 1 (conducted in South Africa), healthy non-pregnant participants received GBS6, GBS6 + aluminum phosphate (AlPO

Indexed as

Pregnancy Complications, InfectiousStreptococcal InfectionsStreptococcal VaccinesStreptococcus agalactiaeAdultAluminum CompoundsFemaleHumansInfantInfant, NewbornPhosphatesPregnancySouth AfricaUnited KingdomVaccinationVaccines, ConjugateAluminum Compoundsaluminum phosphatePhosphatesStreptococcal VaccinesVaccines, Conjugate

Identifiers

PMID42521820
PMCPMC13472963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.